Institut de Chimie des Substances Naturelles, CNRS UPR2301, Univ. Paris Sud., Université Paris-Saclay, 91190 Gif-Sur-Yvette, France.
Analyst. 2018 Jul 9;143(14):3458-3464. doi: 10.1039/c8an00434j.
Diffusion-ordered NMR spectroscopy (DOSY) is a powerful method for the analysis of mixtures. Classic DOSY methods require several minutes of acquisition, and we show here that DOSY experiments can be recorded in less than one second for the challenging case of solution mixtures in low-viscosity solvents. The proposed method relies on a spatial encoding of the diffusion dimension, for which convection-compensation and spectral-selection strategies are introduced. The method is illustrated with the analysis of a reaction mixture, and more accurate estimates of the diffusion coefficients are obtained.
扩散排序核磁共振波谱（DOSY）是分析混合物的有力方法。经典的 DOSY 方法需要几分钟的采集时间，而我们在这里展示了对于低粘度溶剂中溶液混合物这种具有挑战性的情况，DOSY 实验可以在不到一秒的时间内记录。所提出的方法依赖于扩散维度的空间编码，为此引入了对流补偿和谱选择策略。该方法通过对反应混合物的分析进行了说明，并获得了更准确的扩散系数估计值。
