Research Institute for Sustainable Chemistry, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba Central 5-2, 1-1-1 Higashi, Tsukuba, Ibaraki, 305-8565, Japan.
Bioproduction Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba Central 6-9, 1-1-1 Higashi, Tsukuba, Ibaraki, 305-8566, Japan.
Appl Microbiol Biotechnol. 2018 Aug;102(16):6877-6884. doi: 10.1007/s00253-018-9160-9. Epub 2018 Jun 20.
Mannosylerythritol lipids (MELs) are a type of glycolipid biosurfactant produced by basidiomycetous yeasts, most notably those belonging to the genera Pseudozyma and Ustilago. Mannosylerythritol lipids are environmentally friendly and possess many unique functions, such as gene delivery, bio-activation, and human skin repair, and thus have potential applications in cosmetic, pharmaceutical, agriculture, food, and environmental industries. However, MELs will require overcoming same issues related to the commercialization, e.g., expansion of the structure and function variety and cost reduction. In the past decade, various studies have attempted to tailor production of targeted MELs in order to expand the utility of these biosurfactants. Moreover, the rapid development of genomic sequencing techniques will enhance our ability to modify MEL producers. In this review, we focus on current research into the tailored production of MELs, including conventional and advanced approaches.
甘露糖赤藓糖醇脂质（MELs）是一种由担子菌酵母产生的糖脂生物表面活性剂，特别是那些属于假丝酵母属和黑粉菌属的酵母。甘露糖赤藓糖醇脂质对环境友好，具有许多独特的功能，如基因传递、生物激活和人类皮肤修复，因此在化妆品、制药、农业、食品和环境行业具有潜在的应用。然而，MELs 将需要克服与商业化相关的同样问题，例如扩大结构和功能的多样性和降低成本。在过去的十年中，各种研究试图定制目标 MELs 的生产，以扩大这些生物表面活性剂的用途。此外，基因组测序技术的快速发展将提高我们修饰 MEL 生产者的能力。在这篇综述中，我们重点介绍了目前对 MEL 定制生产的研究，包括传统和先进的方法。
