Molecular Physiology, Institute of Cardiovascular Physiology, University Medical Center, Georg-August-University, Humboldtallee 23, 37073, Göttingen, Germany.
Department of Dermatology, Venereology and Allergology, University Medical Center, Georg-August-University, Göttingen, Germany.
Pflugers Arch. 2018 Aug;470(8):1149-1163. doi: 10.1007/s00424-018-2162-8. Epub 2018 Jun 21.
The important role of mitochondria in cancer biology is gaining momentum. With their regulation of cell survival, metabolism, basic cell building blocks, and immunity, among other functions, mitochondria affect not only cancer progression but also the response and resistance to current treatments. Calcium ions are constantly shuttled in and out of mitochondria; thus, playing an important role in the regulation of various cellular processes. The mitochondrial calcium uniporter (MCU) channel and its associated regulators transport calcium across the inner mitochondrial membrane to the mitochondrial matrix. Due to this central role and the capacity to affect cell behavior and fate, the MCU complex is being investigated in different cancers and cancer-related conditions. Here, we review current knowledge on the role of the MCU complex in multiple cancer types and models; we also provide a perspective for future research and clinical considerations.
线粒体在癌症生物学中的重要作用正在受到越来越多的关注。线粒体调节细胞存活、代谢、基本细胞构建块和免疫等功能，不仅影响癌症的进展，还影响对当前治疗的反应和耐药性。钙离子不断地在线粒体内外穿梭，因此在调节各种细胞过程中起着重要作用。线粒体钙单向转运体（MCU）通道及其相关调节剂将钙转运穿过线粒体内膜到线粒体基质。由于这个核心作用以及影响细胞行为和命运的能力，MCU 复合物正在不同的癌症和与癌症相关的疾病中进行研究。在这里，我们综述了 MCU 复合物在多种癌症类型和模型中的作用的现有知识，并为未来的研究和临床考虑提供了一个视角。
