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实验性慢性子宫肌层子宫内膜炎期间骨髓多能间充质基质细胞对Wistar大鼠子宫壁血液和淋巴管系统的影响

Effect of Bone Marrow Multipotent Mesenchymal Stromal Cells on Blood and Lymphatic Vasculature in Uterine Wall of Wistar Rats during Experimental Chronic Metroendometritis.

作者信息

Koroleva E G, Dergacheva T I, Shurlygina A V, Poveshchenko O V, Krasil'nikov S E, Konenkov V I

机构信息

Research Institute of Experimental and Clinical Lymphology, Federal Research Center of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia.

Novosibirsk Regional Clinical Oncology Health Center, Novosibirsk, Russia.

出版信息

Bull Exp Biol Med. 2018 Jun;165(2):205-208. doi: 10.1007/s10517-018-4130-x. Epub 2018 Jun 20.

Abstract

The study examined the effect of bone marrow multipotent mesenchymal stromal cells and their products secreted into the conditioned medium on uterine microcirculatory bed in Wistar rats during chronic inflammation. The parameters of blood and lymphatic microcirculation in the uterus changed in various directions in relation to the administration routes of biomedical cell product, which is important when the cell therapy is employed in the treatment of inflammatory-degenerative alterations in the lesser pelvis organs.

摘要

该研究考察了骨髓多能间充质基质细胞及其分泌到条件培养基中的产物对慢性炎症期间Wistar大鼠子宫微循环床的影响。子宫内血液和淋巴微循环的参数因生物医学细胞产品的给药途径不同而朝不同方向变化,这在细胞疗法用于治疗盆腔器官炎症性退行性病变时具有重要意义。

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