Dergacheva T I, Shurlygina A V, Starkova E V, Poveshchenko O V, Klimontov V V, Konenkov V I
Research Institute of Clinical and Experimental Lymphology, Affiliated Branch of the Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia.
Bull Exp Biol Med. 2019 Nov;168(1):168-172. doi: 10.1007/s10517-019-04669-9. Epub 2019 Nov 25.
We studied the effects of intravenous and lymphotropic administration of bone marrow multipotent mesenchymal stromal cells and products secreted by these cells into conditioned medium on the blood and lymph circulation in the uterus and ovaries, as well as on folliculogenesis in female Wistar rats. It was shown that stromal cells and conditioned media of these cells administered via both routes lead to an increase in the number and diameter of blood vessels in the uterine wall and in the cortical layer of the ovaries. Neither mesenchymal stromal cells, not conditioned media affected the ovarian follicular apparatus.
我们研究了静脉内和向淋巴组织给药骨髓多能间充质基质细胞以及这些细胞分泌到条件培养基中的产物，对雌性Wistar大鼠子宫和卵巢的血液及淋巴循环，以及卵泡发生的影响。结果表明，通过这两种途径给药的基质细胞及其条件培养基均可导致子宫壁和卵巢皮质层血管数量增加、血管直径增大。间充质基质细胞和条件培养基均未影响卵巢卵泡结构。
