Research Institute of Clinical and Experimental Lymphology - Affiliated Branch of Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia.
Bull Exp Biol Med. 2022 Aug;173(4):534-538. doi: 10.1007/s10517-022-05577-1. Epub 2022 Sep 5.
Induced inflammation of reproductive organs in female Wistar rats was associated with an increase in the diameters of arteries and veins and number of blood vessels in the ovary medulla in combination with an increase in the number of lymphatic vessels; these changes were accompanied by reduction of the ovarian reserve and number of yellow bodies. Intravenous and submucosal injection of bone marrow multipotent mesenchymal stromal cells (BМ-ММSC) led to further increase in the diameters of arteries and veins and number of primordial and primary follicles. The injection of conditioned medium of BМ-ММSC cultures generally produced the same effects, which could demonstrate the secretory mechanisms of their influence on local angiogenesis and folliculogenesis.
诱导雌性 Wistar 大鼠生殖器官炎症与卵巢髓质中动静脉直径和血管数量增加以及淋巴管数量增加有关; 这些变化伴随着卵巢储备和黄体数量减少。静脉内和黏膜下注射骨髓多能间充质基质细胞（BМ-ММSC）导致动静脉直径和原始卵泡和初级卵泡数量进一步增加。BМ-ММSC 培养物的条件培养基的注射通常产生相同的效果，这可以证明它们对局部血管生成和卵泡发生影响的分泌机制。
