基于DNA三链体结构的pH触发型DNA纳米开关和纳米器件的设计与表征
Design and Characterization of pH-Triggered DNA Nanoswitches and Nanodevices Based on DNA Triplex Structures.
作者信息
Idili Andrea, Ricci Francesco
机构信息
Department of Chemistry, University of Rome Tor Vergata, Rome, Italy.
出版信息
Methods Mol Biol. 2018;1811:79-100. doi: 10.1007/978-1-4939-8582-1_6.
Triplex DNA is becoming a very useful domain to design pH-triggered DNA nanoswitches and nanodevices. The high versatility and programmability of triplex DNA interactions allows the integration of pH-controllable modules into DNA-based reactions and self-assembly processes. Here, we describe the procedure to characterize DNA-based triplex nanoswitches and more in general pH-triggered structure-switching mechanisms. Procedures to characterize pH-triggered DNA nanodevices will be useful for many applications in the field of biosensing, drug delivery systems and smart nanomaterials.
三链DNA正成为设计pH触发的DNA纳米开关和纳米器件的一个非常有用的领域。三链DNA相互作用的高度通用性和可编程性使得将pH可控模块整合到基于DNA的反应和自组装过程中成为可能。在这里，我们描述了表征基于DNA的三链纳米开关以及更一般的pH触发结构转换机制的程序。表征pH触发的DNA纳米器件的程序将对生物传感、药物递送系统和智能纳米材料领域的许多应用有用。
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