基于三聚体-螺旋分子开关的 DNA 逻辑组装用于细胞外 pH 成像。
DNA logic assembly powered by a triplex-helix molecular switch for extracellular pH imaging.
机构信息
College of Chemistry and Chemical Engineering, Qingdao University, Qingdao 266071, P. R. China.
出版信息
Chem Commun (Camb). 2018 Jul 26;54(61):8498-8501. doi: 10.1039/c8cc04615h.
PMID:30003199
Abstract
We demonstrate a strategy for pH-programmable self-assembly of DNA nanostructures by taking advantage of the pH dependence of reverse Hoogsteen interactions for a triplex-helix molecular switch. This strategy is successfully applied to the construction of molecular logic gates and imaging of extracellular pH.
摘要
我们展示了一种通过利用反 Hoogsteen 相互作用的 pH 依赖性来实现 DNA 结构可编程自组装的策略，该策略用于构建三聚体-螺旋分子开关。该策略成功应用于构建分子逻辑门和检测细胞外 pH 值。
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