Rahrotaban Sedigheh, Nikparto Nariman, Yousefizadeh Parham, Kharazifard Mohammad Javad, Derakhshan Samira
Department of Oral and Maxillofacial Pathology, Tehran University of Medical Sciences, School of Dentistry, TEHRAN, IRAN.
Turk Patoloji Derg. 2018;34(3):220-224. doi: 10.5146/tjpath.2018.01433.
The purpose of this study was to assess and compare fascin expression in 4 lesions which differ in aggressiveness: odontogenic keratocyst, dentigerous cyst and two types of ameloblastoma (solid and unicystic), and to find out whether fascin expression is associated with aggressiveness of these lesions or not.
Nine solid ameloblastomas , 12 unicystic ameloblastomas, 13 odontogenic keratocyst and 12 dentigerous cyst were assessed in this study. The slides were examined at x400 magnification. Finally the lesions were divided into two groups based on microscopic examination, "low expression" and "high expression".
There were no significant differences between the lesions, except that fascin expression was slightly higher in unicystic ameloblastomas in comparison to other groups in intensity and count of the immunostaining cells.
The results of this study suggest that local aggressiveness does not result in fascin expression. We suggest more studies with more samples, assessing expression of different proteins be done in the future.
本研究旨在评估和比较4种侵袭性不同的病变中丝状肌动蛋白（fascin）的表达情况，这些病变包括牙源性角化囊肿、含牙囊肿以及两种类型的成釉细胞瘤（实性和单囊性），并探究fascin表达是否与这些病变的侵袭性相关。
本研究评估了9例实性成釉细胞瘤、12例单囊性成釉细胞瘤、13例牙源性角化囊肿和12例含牙囊肿。玻片在400倍放大倍数下进行检查。最后，根据显微镜检查将病变分为两组，即“低表达”和“高表达”。
除单囊性成釉细胞瘤中fascin表达在免疫染色细胞强度和数量上比其他组略高外，各病变之间无显著差异。
本研究结果表明局部侵袭性不会导致fascin表达。我们建议未来进行更多样本的研究，评估不同蛋白质的表达情况。
