Coleman H G, Altini M, Groeneveld H T
Department of Oral Pathology, University of the Witwatersrand, Johannesburg, South Africa.
J Oral Pathol Med. 1996 Sep;25(8):436-40. doi: 10.1111/j.1600-0714.1996.tb00293.x.
The aim of this study was to determine whether nucleolar organizer regions (AgNORs) may be of value in distinguishing various odontogenic cysts from the unicystic ameloblastoma. Histological sections were prepared from fifteen cases each of odontogenic keratocyst, residual cyst, dentigerous cyst, unicystic ameloblastoma and conventional ameloblastoma. In each case intra-nuclear AgNOR dots were counted in 100 consecutive basal nuclei. Statistical comparison of the least squares means showed that those areas of unicystic ameloblastomas lined by characteristic epithelium had a significantly lower AgNOR count than the other groups (P < 0.05). The dentigerous cysts had significantly higher AgNOR counts than the residual cysts and unicystic ameloblastomas (P < 0.05). These differences may or may not be indicative of variations in metabolic, proliferative or transcriptional activity. We conclude that AgNOR counts are not of diagnostic significance and cannot be used to distinguish the various odontogenic cysts from one another nor from the unicystic ameloblastoma.
本研究的目的是确定核仁组织区（AgNORs）在区分各种牙源性囊肿与单囊性成釉细胞瘤方面是否有价值。从牙源性角化囊肿、残余囊肿、含牙囊肿、单囊性成釉细胞瘤和传统成釉细胞瘤各15例制备组织学切片。在每例中，对100个连续的基底细胞核内的AgNOR点进行计数。最小二乘均值的统计比较显示，由特征性上皮衬里的单囊性成釉细胞瘤区域的AgNOR计数显著低于其他组（P < 0.05）。含牙囊肿的AgNOR计数显著高于残余囊肿和单囊性成釉细胞瘤（P < 0.05）。这些差异可能表明或不表明代谢、增殖或转录活性的变化。我们得出结论，AgNOR计数没有诊断意义，不能用于区分各种牙源性囊肿彼此之间以及与单囊性成釉细胞瘤。
