Moonen M, Lancellotti P
Service de Cardiologie, CHU Sart Tilman, Liège, Belgique.
Rev Med Liege. 2018 May;73(5-6):269-276.
Myocarditis is an illness characterized by myocardial infiltration with inflammatory cells and non-ischemic myocytic necrosis. The clinical presentation of myocarditis varies widely and diagnosis is sometimes difficult to establish. The current incidence of myocarditis is also difficult to determine as endomyocardial biopsy, the diagnostic gold standard, is unfrequently used, or even not justified. The leading causes are infections, immune-mediated injury and toxins. Prognosis is most often good but, in some patients, the disease can be fulminant with progression to cardiogenic shock, or occurrence of sudden cardiac death. Prognosis in myocarditis patients varies according to the underlying aetiology. Treatment is generally symptomatic, but in some cases, a specific therapy is appropriated as a function of the corresponding aetiology. This paper aims to review current knowledge concerning myocarditis, with particular emphasis on «urgent» situations.
心肌炎是一种以炎性细胞浸润心肌和非缺血性心肌细胞坏死为特征的疾病。心肌炎的临床表现差异很大,有时难以确诊。由于作为诊断金标准的心肌内膜活检很少使用,甚至不合理,因此目前心肌炎的发病率也难以确定。主要病因是感染、免疫介导损伤和毒素。预后通常良好,但在一些患者中,疾病可能呈暴发性,进展为心源性休克或发生心源性猝死。心肌炎患者的预后因潜在病因而异。治疗一般为对症治疗,但在某些情况下,根据相应病因采用特定治疗方法。本文旨在综述有关心肌炎的现有知识,尤其着重于“紧急”情况。