Pukdeekumjorn Piangpen, Ruangnoo Srisopa, Itharat Arunporn
J Med Assoc Thai. 2016 Jul;99 suppl 4:S138-43.
Cinnamomum porrectum (Roxb.) Kosterm. (Thai name Thep-tha-ro) is a medicinal and aromatic tree mostly distributed throughout southern Thailand. It is traditionally used as spices, vegetable, carminative, tonic, febrifuge and postpartum care for being anti-inflammation whilst chemical components and its anti-inflammatory activity of this plant extracts were rarely reported.
To investigate the anti-inflammatory activity of the crude extracts from different extraction method of C. porrectum wood.
Steam distillation, maceration in 50% or 95% ethanol or decoction method were used for extraction. The extracts were obtained as oil, ethanolic or aqueous extracts, respectively. These extracts were tested in vitro for antiinflammatory activity using nitric inhibitory assay by determining the inhibitory activity on lipopolysaccharide (LPS) induced nitric oxide production in RAW 264.7 cell lines.
The 50%, 95% ethanolic extracts of this plant showed high anti-inflammatory activity (IC50 values as 19.28±2.43 and 13.78±3.76 μg/ml, respectively), where water extract of this plant showed low anti-inflammatory activity (IC50 values >100 μg/ml), oily extracts showed cytotoxicity.
The results revealed that ethanolic extracts showed strong anti-inflammatory activity; therefore these extracts of Cinnamomum porrectum should be further developed as a health product for treatment of inflammation.
长梗樟（泰国名：Thep-tha-ro）是一种药用芳香树，主要分布于泰国南部。它传统上用作香料、蔬菜、驱风剂、滋补剂、退烧药及产后护理，具有抗炎作用，但其化学成分及其植物提取物的抗炎活性鲜有报道。
研究长梗樟木材不同提取方法所得粗提物的抗炎活性。
采用水蒸气蒸馏法、50%或95%乙醇浸渍法或煎煮法进行提取，分别得到油提取物、乙醇提取物或水提取物。通过测定对脂多糖（LPS）诱导的RAW 264.7细胞系一氧化氮生成的抑制活性，采用一氧化氮抑制试验在体外检测这些提取物的抗炎活性。
该植物的50%、95%乙醇提取物显示出较高的抗炎活性（IC50值分别为19.28±2.43和13.78±3.76μg/ml），而该植物的水提取物抗炎活性较低（IC50值>100μg/ml），油提取物具有细胞毒性。
结果表明乙醇提取物具有较强的抗炎活性；因此，长梗樟的这些提取物应进一步开发为治疗炎症的保健品。
