Siriwattanasatorn Metar, Panthong Sumalee, Itharat Arunporn
J Med Assoc Thai. 2016 Jul;99 Suppl 4:S144-52.
Many people suffer from acute pharyngitis which is caused by bacteria, especially Streptococcus pyogenes. Patients consume antibiotics even though antibiotic drugs have been causing adverse effects. Ten Thai medicinal plant species commonly used for treating acute pharyngitis may reduce the use of antibiotics.
To determine the antimicrobial activity of ten Thai medicinal plant species most commonly used for acute pharyngitis.
Plant materials were extracted with 95% ethanol or distilled water then concentrated and dried. Antimicrobial activity of ten Thai medicinal plant species were determined using two standard assays, broth dilution method for minimal inhibitory concentration value (MIC) and agar dilution method for minimal bactericidal concentration value (MBC), against microorganisms that cause acute pharyngitis.
The ethanolic extract of Garcinia mangostana showed the strongest activity of both assays, MIC value in range of 0.6-9.8 μg/ml and MBC value in range of 1.2-625 μg/ml, which inhibited all the bacteria tested and particularly inhibited S. pyogenes ATCC 19615 as the most common cause of acute pharyngitis with the value of MIC and MBC at 0.6 and 1.2 μg/ml, respectively. The second highest antimicrobial activity was the ethanolic extract of Glycyrrhiza glabra with MIC value in range of 39-156 μg/ml and MBC value in range of 78-312 μg/ml and it showed strong activity against S. pyogenes ATCC 19615, S. pneumoniae ATCC 49619 and S. mutans ATCC 25175 with the value of MIC and MBC at 39 and 78 μg/ml, respectively.
The ethanolic extract of G. mangostana and G. glabra are the two best choice for acute pharyngitis treatment.
许多人患有由细菌引起的急性咽炎，尤其是化脓性链球菌。尽管抗生素药物会产生不良反应，但患者仍会使用。十种常用于治疗急性咽炎的泰国药用植物可能会减少抗生素的使用。
确定十种最常用于治疗急性咽炎的泰国药用植物的抗菌活性。
将植物材料用95%乙醇或蒸馏水提取，然后浓缩并干燥。使用两种标准测定方法来确定十种泰国药用植物的抗菌活性，即肉汤稀释法测定最低抑菌浓度值（MIC）和琼脂稀释法测定最低杀菌浓度值（MBC），以检测引起急性咽炎的微生物。
山竹乙醇提取物在两种测定方法中均表现出最强的活性，MIC值在0.6 - 9.8μg/ml范围内，MBC值在1.2 - 625μg/ml范围内，它能抑制所有测试细菌，尤其对作为急性咽炎最常见病因的化脓性链球菌ATCC 19615抑制作用最强，MIC和MBC值分别为0.6和1.2μg/ml。第二高的抗菌活性是光果甘草乙醇提取物，MIC值在39 - 156μg/ml范围内，MBC值在78 - 312μg/ml范围内，它对化脓性链球菌ATCC 19615、肺炎链球菌ATCC 49619和变形链球菌ATCC 25175表现出较强活性，MIC和MBC值分别为39和78μg/ml。
山竹和光果甘草的乙醇提取物是治疗急性咽炎的两种最佳选择。
