Moshé S L, Okada R, Albala B J
Brain Res. 1985 Jul 1;337(2):368-72. doi: 10.1016/0006-8993(85)90077-0.
Recent data indicate that the substantia nigra is an important site in a circuitry involved in the modification of various experimental seizures with neocortical and limbic involvement. Since there are no direct nigral projections to either area, we assumed that the nigral effects on seizures are relayed by other sites such as the thalamus. To evaluate this hypothesis we produced bilateral high-radiofrequency thermocoagulative lesions of the ventromedial (VM) thalamic nuclei which receive the nigral efferents in the rat. We determined the susceptibility of lesioned and control adult rats to the development of flurothyl seizures 2 and 4 weeks later. The latency to the onset of a generalized seizure was considered as the convulsive threshold. There were no differences in the mean latencies between the groups. The results suggest that bilateral destruction of the VM thalamic nuclei does not modify the susceptibility to the development of flurothyl seizures in the rat.
近期数据表明，黑质是参与各种伴有新皮质和边缘系统受累的实验性癫痫发作改变的神经回路中的一个重要部位。由于黑质与这两个区域均无直接投射，我们推测黑质对癫痫发作的影响是通过丘脑等其他部位传递的。为评估这一假说，我们对大鼠腹内侧丘脑核进行了双侧高射频热凝损伤，该丘脑核接收黑质传出纤维。我们在2周和4周后分别测定了损伤组和对照组成年大鼠对氟烷癫痫发作的易感性。全身性癫痫发作开始的潜伏期被视为惊厥阈值。两组的平均潜伏期没有差异。结果表明，双侧损毁腹内侧丘脑核不会改变大鼠对氟烷癫痫发作的易感性。
