Karabelas A B, Walkley S U
Brain Res. 1985 Jul 29;339(2):329-36. doi: 10.1016/0006-8993(85)90099-x.
Postsynaptic potentials evoked by ventrolateral thalamic stimulation were recorded intracellularly from neurons in the precruciate cortex of GM1 mutants with HRP- or LY-loaded microelectrodes. Ganglioside-laden pyramidal neurons exhibiting somal distention and/or meganeurite formation were found to respond to thalamic stimulation with short duration IPSPs. Evoked EPSPs were recorded from two morphologically characterized large basket intrinsic neurons which deployed extensive intracortical axonal arborizations. These findings point to the preservation of intracortical inhibitory networks in the feline model of GM1 gangliosidosis, and to the possibility of abnormal integration of somadendritic inputs in ganglioside-laden pyramidal neurons.
用装载了辣根过氧化物酶（HRP）或鲁米诺黄（LY）的微电极，在细胞内记录GM1突变体前十字皮质神经元对丘脑腹外侧刺激诱发的突触后电位。发现含有神经节苷脂的锥体神经元出现胞体扩张和/或巨神经突形成，对丘脑刺激产生持续时间较短的抑制性突触后电位（IPSPs）。从两个形态特征明确的大型篮状固有神经元记录到诱发的兴奋性突触后电位（EPSPs），这些神经元具有广泛的皮质内轴突分支。这些发现表明在GM1神经节苷脂沉积症的猫模型中皮质内抑制网络得以保留，并且提示含有神经节苷脂的锥体神经元中体细胞树突输入可能存在异常整合。
