[重度贫血和低血糖在贝宁帕拉库某儿科病房儿童重症疟疾死亡中的作用]

[Role of severe anemia and hypoglycemia in severe malaria's mortality in children in a pediatric ward in Parakou (Benin)].

作者信息

Adedemy J D, Agossou J, Alao M J, Noudamadjo A, Ayivi B

机构信息

Maître-assistant de Pédiatrie à la Faculté de Médecine de l'Université de Parakou et au Centre Hospitalier Départemental du Borgou 03 BP 09 Parakou République du Bénin.

Maître-assistant de Pédiatrie à la Faculté de Médecine de l'Université de Parakou et au Centre Hospitalier Départemental du Borgou et, 03 BP 09 Parakou République du Bénin.

出版信息

Mali Med. 2015;30(1):19-24.

PMID:29927153

Abstract

AIMS

In this study, the objective was to determine the proportion of severe anemia and hypoglycemia in severe malaria in children and to identify factors influencing death.

PATIENTS AND METHODS

This is a descriptive and analytic cross-sectional study with prospectively collected data from January to December 2009. It included children from one month to fourteen years of age hospitalized in the Parakou Regional Hospital Center in Benin for severe malaria according to the World Health Organization (WHO) criteria.

RESULTS

Among the 1838 cases, 968 cases (52.6%) had either severe anemia or hypoglycemia or both. Among these, 89% were under 5 years. Biologically, the mean parasite density was 40 062/mm3 and the mean hemoglobin rate was 4.94 g/dl. The average blood glucose was 0.45 g/l. The mortality rate was 8.2%. Death occurrence rate was significantly higher in under five children's group hospitalized for severe anemia and/or hypoglycemia compared to those of the same age group with others forms of severe malaria (p=0,000081).

CONCLUSION

This work suggests the importance of hypoglycemia and anemia among factors associated with death in children's severe malaria.

摘要

目的

本研究旨在确定儿童重症疟疾中重度贫血和低血糖的比例，并确定影响死亡的因素。

患者与方法

这是一项描述性和分析性横断面研究，前瞻性收集了2009年1月至12月的数据。研究对象为根据世界卫生组织（WHO）标准，在贝宁帕拉库地区医院中心住院治疗重症疟疾的1个月至14岁儿童。

结果

在1838例病例中，968例（52.6%）患有重度贫血或低血糖或两者兼有。其中，89%为5岁以下儿童。从生物学角度看，平均寄生虫密度为40062/mm³，平均血红蛋白率为4.94g/dl。平均血糖为0.45g/l。死亡率为8.2%。因重度贫血和/或低血糖住院的5岁以下儿童组的死亡率明显高于同龄其他形式重症疟疾儿童组（p=0.000081）。