硫叶立德与 1,2-二氮杂-1,3-二烯反应构建螺环丙基吡唑酮和双环 4,5-二氢吡唑
Substrate-Controlled Synthesis of Spirocyclopropylpyrazolones and Bicyclic 4,5-Dihydropyrazoles from 1,2-Diaza-1,3-dienes with Sulfur Ylides.
机构信息
Department of Chemistry , Zhejiang Sci-Tech University , Hangzhou , 310018 , P. R. China.
College of Pharmaceutical Science , Zhejiang University , Hangzhou , 310058 , P. R. China.
出版信息
Org Lett. 2018 Jul 6;20(13):3992-3995. doi: 10.1021/acs.orglett.8b01562. Epub 2018 Jun 21.
PMID:29927255
Abstract
Substrate-controlled reactions have been developed for the synthesis of spirocyclopropylpyrazolones and bicyclic 4,5-dihydropyrazoles from 1,2-diaza-1,3-dienes and sulfur ylides. These protocols were carried out under mild reaction conditions without any additives in generally moderate to good yields. Plausible mechanisms for the transformations were proposed.
摘要
已经开发出了底物控制反应，用于从 1,2-二氮-1,3-二烯和硫叶立德合成螺环丙基吡唑酮和双环 4,5-二氢吡唑。这些方案在温和的反应条件下进行，无需添加任何添加剂，通常在中等至良好的收率下进行。提出了这些转化的合理机制。
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