Grewal Dilraj S, Polascik Bryce W, Hoffmeyer Gregory C, Fekrat Sharon
Ophthalmic Surg Lasers Imaging Retina. 2018 Jun 1;49(6):440-444. doi: 10.3928/23258160-20180601-09.
The authors report the optical coherence tomography angiography (OCTA)-based comparative assessment of the retinal microvasculature in a rare pair of 96-year-old female monozygotic twins discordant for Alzheimer's disease (AD). Using automated mapping of the superficial capillary plexus, the authors observed that the twin with advanced AD had a significantly reduced vessel density and a larger foveal avascular zone in the superficial capillary plexus as well as a thinner choroid compared to the twin who was cognitively normal. This unique twin discordance report adds to the evidence supporting the use of retinal microvasculature changes in the superficial capillary plexus on OCTA as a possible noninvasive biomarker for AD. [Ophthalmic Surg Lasers Imaging Retina. 2018;49:440-444.].
作者报告了基于光学相干断层扫描血管造影（OCTA）对一对罕见的96岁患阿尔茨海默病（AD）不一致的女性同卵双胞胎视网膜微血管系统的比较评估。通过对浅表毛细血管丛进行自动绘图，作者观察到，与认知正常的双胞胎相比，患有晚期AD的双胞胎浅表毛细血管丛中的血管密度显著降低，中央凹无血管区更大，脉络膜更薄。这份独特的双胞胎不一致报告进一步证明了，OCTA上浅表毛细血管丛中视网膜微血管变化可作为AD可能的非侵入性生物标志物。[《眼科手术、激光与视网膜成像》。2018年；49:440 - 444。]
