Wu San-Pin, Yu Cheng-Tai, Tsai Sophia Y, Tsai Ming-Jer
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA; Adrienne Helis Malvin Medical Research Foundation, New Orleans, LA 70130, USA.
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.
J Steroid Biochem Mol Biol. 2016 Mar;157:7-12. doi: 10.1016/j.jsbmb.2015.11.011. Epub 2015 Dec 2.
Cell fate specification is a critical process to generate cells with a wide range of characteristics from stem and progenitor cells. Emerging evidence demonstrates that the orphan nuclear receptor COUP-TFII serves as a key regulator in determining the cell identity during embryonic development. The present review summarizes our current knowledge on molecular mechanisms by which COUP-TFII employs to define the cell fates, with special emphasis on cardiovascular and renal systems. These novel insights pave the road for future studies of regenerative medicine.
细胞命运特化是一个从干细胞和祖细胞产生具有广泛特性细胞的关键过程。新出现的证据表明，孤儿核受体COUP-TFII在胚胎发育过程中作为决定细胞身份的关键调节因子。本综述总结了我们目前对COUP-TFII用于定义细胞命运的分子机制的认识，特别强调心血管和肾脏系统。这些新见解为再生医学的未来研究铺平了道路。
