Jun Li, Ming Zhu
Department of Pathology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, P.R. China.
Department of Head and Neck, Zhejiang Tumor Hospital, Hangzhou, Zhejiang 310021, P.R. China.
Oncol Lett. 2018 Jul;16(1):619-622. doi: 10.3892/ol.2018.8682. Epub 2018 May 9.
Heterotopic Warthin's tumor (WT) arising from the cervical lymph nodes is uncommon and WT presenting concomitantly with classical Hodgkin's lymphoma has only been previously reported three times in English literature. The current study presents an unusual case of classical Hodgkin lymphoma (CHL) involving the heterotopic WT in a 59-year-old male. Histopathologic examination revealied a WT with extensive expansion of mixed-cellularity CHL in a lymph node in the right of the neck. Clinical staging was determined as stage IA disease. The patient received four courses of chemotherapy and local consolidative radiotherapy, no evidence of disseminated lymphoma was observed over the 6-month follow-up. To the best of our knowledge, this is the first well documented collision tumor between CHL and heterotopic WT of the cervical lymph nodes. The present case also expands the anatomical site of malignant lymphomas associated with WT.
起源于颈部淋巴结的异位沃辛瘤(WT)并不常见,而同时出现经典型霍奇金淋巴瘤的WT此前在英文文献中仅报道过3次。本研究报告了1例罕见的59岁男性经典型霍奇金淋巴瘤(CHL)累及异位WT的病例。组织病理学检查显示,颈部右侧淋巴结内有1例WT伴混合细胞型CHL广泛扩展。临床分期确定为IA期疾病。该患者接受了4个疗程的化疗和局部巩固放疗,在6个月的随访中未观察到弥漫性淋巴瘤的证据。据我们所知,这是首例有充分记录的CHL与颈部淋巴结异位WT之间的碰撞瘤。本病例还扩展了与WT相关的恶性淋巴瘤的解剖部位。