盐负荷对人促肾上腺皮质激素性高血压的增强作用。

Potentiation of ACTH hypertension in man with salt loading.

作者信息

Whitworth J A, Saines D, Scoggins B A

出版信息

Clin Exp Pharmacol Physiol. 1985 May-Jun;12(3):239-43. doi: 10.1111/j.1440-1681.1985.tb02639.x.

DOI:10.1111/j.1440-1681.1985.tb02639.x

Abstract

ACTH 1 mg/day for 5 days raises systolic blood pressure (SBP) in normotensive and hypertensive subjects on a fixed electrolyte intake of 100 mmol/day sodium (Na) and potassium (K) (Whitworth et al. 1983). The present study examined the effect of Na intake in the high normal range on the haemodynamic and metabolic responses to ACTH. ACTH administration on a 200-300 mmol Na intake increased SBP by 35 mmHg (s.e.m. = 11, n = 5) compared with the 22 mmHg (s.e.m. = 4, n = 12) rise seen on a 100 mmol Na intake in our previous study. These studies suggest that the effects of adrenocortical steroids on blood pressure in man may be magnified by increasing dietary Na intake.

摘要

对于每日固定摄入100毫摩尔钠（Na）和钾（K）的血压正常和高血压受试者，连续5天每天注射1毫克促肾上腺皮质激素（ACTH）可升高收缩压（SBP）（惠特沃思等人，1983年）。本研究考察了高正常范围的钠摄入量对ACTH血液动力学和代谢反应的影响。与我们之前研究中100毫摩尔钠摄入量时收缩压升高22毫米汞柱（标准误=4，n=12）相比，在摄入200 - 300毫摩尔钠时给予ACTH，收缩压升高了35毫米汞柱（标准误=11，n=5）。这些研究表明，增加饮食中的钠摄入量可能会放大肾上腺皮质类固醇对人体血压的影响。