Czepielewski Letícia S, Londero Marina D B, de Sousa Mathias H, Perin Carolina P, Maldonado Helena C, Claudino Felipe C A, Gama Clarissa S
Laboratory of Molecular Psychiatry, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Brazil.
Post Graduate Program in Medicine, Department of Psychiatry, Universidade Federal do Rio Grande do Sul, Brazil.
Schizophr Res Cogn. 2018 Mar 9;12:40-41. doi: 10.1016/j.scog.2018.02.002. eCollection 2018 Jun.
Clozapine is more efficacious than first-generation antipsychotics for positive and negative symptoms, although it is related with serious adverse effects. Because of this profile, it could also have an impact on cognition. Therefore, we evaluated learning ability of 31 treatment-resistant individuals with SZ using clozapine uninterruptedly for 18.23 ± 4.71 years and 26 non-treatment-resistant using other antipsychotics that never used clozapine. Long-term treatment with clozapine did not improve verbal learning ability better than other antipsychotics. Although clozapine has a unique profile for reducing clinical symptoms, it may not have an additional benefit for cognition when started later on the course of schizophrenia.
氯氮平在治疗阳性和阴性症状方面比第一代抗精神病药物更有效，尽管它与严重的不良反应有关。由于这种情况，它也可能对认知产生影响。因此，我们评估了31名使用氯氮平不间断治疗18.23±4.71年的难治性精神分裂症患者和26名使用其他从未使用过氯氮平的抗精神病药物的非难治性患者的学习能力。与其他抗精神病药物相比，长期使用氯氮平并不能更好地改善言语学习能力。尽管氯氮平在减轻临床症状方面具有独特的作用，但在精神分裂症病程后期开始使用时，它可能对认知没有额外的益处。
