Danion Jean-Marie, Huron Caroline, Vidailhet Pierre, Berna Fabrice
Unité INSERM 666 Physiopathologie Clinique et Expérimentale de la Schizophrénie, Strasbourg, France.
Can J Psychiatry. 2007 Nov;52(11):693-701. doi: 10.1177/070674370705201103.
To achieve a better understanding of the functional mechanisms underlying episodic memory dysfunction in schizophrenia, which is a prerequisite for unravelling schizophrenia's neural correlates in neuroimaging studies and, more generally, for developing an integrated approach to the pathophysiology of schizophrenia. It is also crucial for developing cognitive remediation.
This paper reviews empirical evidence of episodic memory dysfunction in schizophrenia obtained with reference to various theoretical models of episodic memory.
All the studies converge to show a significant impairment of the critical feature of episodic memory: conscious recollection. Schizophrenia is also associated with a defect of autobiographical memory. The episodic memory dysfunction results from a predominant failure of strategic processing at encoding, although an impairment of strategic processing at retrieval cannot be ruled out. The possibility that it is not the execution of the encoding strategies that is defective but, rather, their self-initiation by the patients is plausible.
These findings may explain some behavioural abnormalities associated with schizophrenia, notably, inadequate functional outcomes in everyday life. They may also have implications for cognitive remediation and better social and work functioning of patients with schizophrenia.
为了更好地理解精神分裂症发作性记忆功能障碍背后的功能机制，这是在神经影像学研究中揭示精神分裂症神经关联的前提条件，更广泛地说，是为了开发一种针对精神分裂症病理生理学的综合方法。这对于开展认知康复治疗也至关重要。
本文回顾了参考各种情节性记忆理论模型获得的精神分裂症发作性记忆功能障碍的实证证据。
所有研究都一致表明，情节性记忆的关键特征——有意识回忆——存在显著损害。精神分裂症还与自传体记忆缺陷有关。发作性记忆功能障碍主要是由于编码时策略性加工的失败，尽管不能排除检索时策略性加工受损的情况。患者编码策略执行并无缺陷，而是策略自我启动存在问题，这种可能性是合理的。
这些发现可能解释了一些与精神分裂症相关的行为异常，尤其是日常生活中功能结果不佳的情况。它们也可能对认知康复以及精神分裂症患者更好地融入社会和工作产生影响。
