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Clinical outcomes of abnormal cervical cytology and human papillomavirus-related lesions in patients with organ transplantation: 11-year experience at a single institution.器官移植患者异常宫颈细胞学和人乳头瘤病毒相关病变的临床转归：单中心 11 年经验。
Int J Clin Oncol. 2016 Aug;21(4):730-734. doi: 10.1007/s10147-015-0940-2. Epub 2015 Dec 22.
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HPV Carcinomas in Immunocompromised Patients.免疫功能低下患者的人乳头瘤病毒相关癌
J Clin Med. 2015 Jan 29;4(2):260-81. doi: 10.3390/jcm4020260.
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Everolimus-based immunosuppression therapy for BK virus nephropathy.依维莫司为基础的免疫抑制疗法治疗BK病毒肾病
Transplant Proc. 2015 Jan-Feb;47(1):57-61. doi: 10.1016/j.transproceed.2014.11.008.
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Review of cytomegalovirus infection findings with mammalian target of rapamycin inhibitor-based immunosuppressive therapy in de novo renal transplant recipients.审查哺乳动物雷帕霉素靶蛋白抑制剂为基础的免疫抑制治疗在肾移植受者中巨细胞病毒感染的发现。
Transplantation. 2012 Jun 15;93(11):1075-85. doi: 10.1097/TP.0b013e31824810e6.
5
HPV-related (pre)malignancies of the female anogenital tract in renal transplant recipients.女性肾移植受者肛门生殖器部位 HPV 相关（前）恶性肿瘤。
Crit Rev Oncol Hematol. 2012 Nov;84(2):161-80. doi: 10.1016/j.critrevonc.2012.02.008. Epub 2012 Mar 16.
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mTOR as a molecular target in HPV-associated oral and cervical squamous carcinomas.mTOR 作为 HPV 相关口腔和宫颈鳞癌的分子靶点。
Clin Cancer Res. 2012 May 1;18(9):2558-68. doi: 10.1158/1078-0432.CCR-11-2824. Epub 2012 Mar 12.
7
A clinical study of cervical dysplasia in long-term survivors of allogeneic stem cell transplantation.异基因干细胞移植后长期生存者的宫颈发育不良的临床研究。
Biol Blood Marrow Transplant. 2012 May;18(5):747-53. doi: 10.1016/j.bbmt.2011.09.012. Epub 2011 Oct 1.
8
Cytomegalovirus incidence between everolimus versus mycophenolate in de novo renal transplants: pooled analysis of three clinical trials.在肾移植受者中，依维莫司与吗替麦考酚酯之间巨细胞病毒感染的发生率：三项临床试验的汇总分析。
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9
Inhibition of mTOR blocks the anti-inflammatory effects of glucocorticoids in myeloid immune cells.mTOR 抑制作用阻断了糖皮质激素在髓样免疫细胞中的抗炎作用。
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The multifunctional role of mTOR in innate immunity: implications for transplant immunity.mTOR 在天然免疫中的多功能作用：对移植免疫的影响。
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依维莫司与女性肾移植受者的乳头瘤病毒病变：一例报告

Everolimus and papillomavirus lesions in female renal transplant recipient: A case report.

作者信息

Simundic T, Zibar L, Sego K

机构信息

Department of Nephrology, University Hospital Center Osijek, Huttlerova 4, 31000 Osijek, Croatia.

Faculty of Medicine, University of Osijek, Huttlerova 4, 31000 Osijek, Croatia.

出版信息

Gynecol Oncol Rep. 2018 Jun 4;25:63-64. doi: 10.1016/j.gore.2018.06.001. eCollection 2018 Aug.

DOI:10.1016/j.gore.2018.06.001
PMID:29928683
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6008281/
Abstract

We describe the case of a transplanted patient with high-risk HPV infection that manifested as multiple genital condylomas and abnormal Papanicolaou (Pap) smear. Her immunosuppressants were corticosteroids, cyclosporine, and azathioprine. Since gynecologic treatments to eradicate condylomas were completely unsuccessful, cyclosporine was replaced by everolimus. Soon after, condylomas disappeared, HPV status became negative, and Pap smear returned to normal and has remained normal since.

摘要

我们描述了一例高危人乳头瘤病毒（HPV）感染的移植患者，其表现为多发性生殖器湿疣和巴氏涂片异常。她使用的免疫抑制剂有皮质类固醇、环孢素和硫唑嘌呤。由于根除湿疣的妇科治疗完全失败，环孢素被依维莫司取代。此后不久，湿疣消失，HPV状态转为阴性，巴氏涂片恢复正常且至今一直保持正常。