依维莫司与女性肾移植受者的乳头瘤病毒病变：一例报告
Everolimus and papillomavirus lesions in female renal transplant recipient: A case report.
作者信息
Simundic T, Zibar L, Sego K
机构信息
Department of Nephrology, University Hospital Center Osijek, Huttlerova 4, 31000 Osijek, Croatia.
Faculty of Medicine, University of Osijek, Huttlerova 4, 31000 Osijek, Croatia.
出版信息
Gynecol Oncol Rep. 2018 Jun 4;25:63-64. doi: 10.1016/j.gore.2018.06.001. eCollection 2018 Aug.
Abstract
We describe the case of a transplanted patient with high-risk HPV infection that manifested as multiple genital condylomas and abnormal Papanicolaou (Pap) smear. Her immunosuppressants were corticosteroids, cyclosporine, and azathioprine. Since gynecologic treatments to eradicate condylomas were completely unsuccessful, cyclosporine was replaced by everolimus. Soon after, condylomas disappeared, HPV status became negative, and Pap smear returned to normal and has remained normal since.
摘要
我们描述了一例高危人乳头瘤病毒（HPV）感染的移植患者，其表现为多发性生殖器湿疣和巴氏涂片异常。她使用的免疫抑制剂有皮质类固醇、环孢素和硫唑嘌呤。由于根除湿疣的妇科治疗完全失败，环孢素被依维莫司取代。此后不久，湿疣消失，HPV状态转为阴性，巴氏涂片恢复正常且至今一直保持正常。
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Int J Clin Oncol. 2016 Aug;21(4):730-734. doi: 10.1007/s10147-015-0940-2. Epub 2015 Dec 22.
2
HPV Carcinomas in Immunocompromised Patients.免疫功能低下患者的人乳头瘤病毒相关癌
J Clin Med. 2015 Jan 29;4(2):260-81. doi: 10.3390/jcm4020260.
3
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Transplant Proc. 2015 Jan-Feb;47(1):57-61. doi: 10.1016/j.transproceed.2014.11.008.
4
Review of cytomegalovirus infection findings with mammalian target of rapamycin inhibitor-based immunosuppressive therapy in de novo renal transplant recipients.审查哺乳动物雷帕霉素靶蛋白抑制剂为基础的免疫抑制治疗在肾移植受者中巨细胞病毒感染的发现。
Transplantation. 2012 Jun 15;93(11):1075-85. doi: 10.1097/TP.0b013e31824810e6.
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6
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