Richart R M
Columbia University College of Physicians and Surgeons, New York, New York.
Cancer. 1987 Oct 15;60(8 Suppl):1951-9. doi: 10.1002/1097-0142(19901015)60:8+<1951::aid-cncr2820601505>3.0.co;2-u.
The evidence for human papillomavirus (HPV) playing a role in the pathogenesis of lower genital neoplasia is reviewed. It is likely that this group of viruses is etiologically important. It is suggested that cervical lesions be diagnosed as flat condyloma if they contain HPV types six or 11 and as cervical intraepithelial neoplasia (CIN) if they are confined to the epithelium and contain HPV Types 16 or 18 or other types associated with neoplasia. Patients with a Papanicolaou (PAP) smear or clinical evidence of HPV infection in the genital tract should be examined colposcopically, invasive cancer should be excluded, and the HPV-induced lesions should be identified and eradicated.
本文综述了人乳头瘤病毒（HPV）在低位生殖道肿瘤发病机制中作用的证据。这类病毒在病因学上可能具有重要意义。建议将含有6型或11型HPV的宫颈病变诊断为扁平湿疣，而局限于上皮层且含有16型、18型HPV或其他与肿瘤相关型别的病变诊断为宫颈上皮内瘤变（CIN）。对巴氏（PAP）涂片检查或有生殖道HPV感染临床证据的患者，应进行阴道镜检查，排除浸润癌，识别并消除HPV引起的病变。
