PMI R&D, Philip Morris Products S.A., Part of Philip Morris International Group of Companies, Quai Jeanrenaud 5, CH-2000, Neuchâtel, Switzerland.
PMI R&D, Philip Morris Products S.A., Part of Philip Morris International Group of Companies, Quai Jeanrenaud 5, CH-2000, Neuchâtel, Switzerland.
Regul Toxicol Pharmacol. 2018 Aug;97:103-109. doi: 10.1016/j.yrtph.2018.06.011. Epub 2018 Jun 19.
Tobacco-specific nitrosamines (TSNA) levels in tobacco cut filler and cigarette smoke were measured in more than 1000 commercially available cigarettes sampled between 2008 and 2014. Relative contributions to their transfer from tobacco to the mainstream smoke in terms of direct transfer by distillation, pyrorelease, and pyrosynthesis were evaluated on the basis of the comparison with the transfer of nicotine from tobacco to smoke. N'-nitrosonornicotine (NNN) was transferred essentially by distillation, while N'-nitrosoanatabine (NAT), 4-(methylnitrosamino)-1-(3-bipyridyl)-1-butanone (NNK) and N'-nitrosoanabasine (NAB) were transferred by pyrorelease or pyrosynthesis as well. In the case of the Tobacco Heating System 2.2, the transfer of nicotine from tobacco to the aerosol was similar to that observed for cigarettes, while the % transfer of TSNAs from tobacco to THS 2.2 aerosol was 2-3 times lower than in cigarettes. This difference is due to the fact that the tobacco is heated instead of burnt resulting in a lower direct transfer by distillation and a lower if any contribution of pyrosynthesis or pyrorelease.
在 2008 年至 2014 年间，对 1000 多种市售卷烟的烟草填充料和卷烟烟雾中的烟草特异性亚硝胺（TSNA）水平进行了测量。基于与尼古丁从烟草转移到烟雾中的转移情况的比较，评估了从烟草到主流烟雾中直接转移、热蒸馏释放、热合成这三种途径对其转移的相对贡献。N'-亚硝基降烟碱（NNN）主要通过蒸馏转移，而 N'-亚硝基去甲烟碱（NAT）、4-（甲基亚硝氨基）-1-（3-吡啶基）-1-丁酮（NNK）和 N'-亚硝基降烟碱（NAB）则通过热蒸馏释放或热合成转移。对于加热不燃烧系统 2.2，尼古丁从烟草转移到气溶胶中的情况与卷烟类似，而从烟草到 THS 2.2 气溶胶中转移的 TSNA 百分比则比卷烟低 2-3 倍。这种差异是由于烟草被加热而不是燃烧，导致蒸馏直接转移减少，热合成或热蒸馏释放的贡献降低（如果有贡献的话）。
