印度香烟的烟草及主流烟雾中的烟草特有亚硝胺

Tobacco-specific N-nitrosamines in tobacco and mainstream smoke of Indian cigarettes.

作者信息

Kumar R, Siddiqi M, Tricker A R, Preussmann R

机构信息

Department of Pharmaceutical Sciences, University of Kashmir, Srinagar, Jammu, India.

出版信息

Food Chem Toxicol. 1991 Jun;29(6):405-7. doi: 10.1016/0278-6915(91)90081-h.

DOI:10.1016/0278-6915(91)90081-h

PMID:1874469

Abstract

Different brands of Indian cigarettes were analysed, by gas chromatography-thermal energy analysis, for the presence of carcinogenic tobacco-specific N-nitrosamines (TSNA) in both tobacco and mainstream smoke. Preformed TSNA in cigarette tobacco ranged between 68 and 730 ng N-nitrosonornicotine (NNN)/cigarette, between 19 and 174 ng 4-(N-nitrosomethylamino)-1-(3-pyridyl)-1-butanone (NNK)/cigarette and between 98 and 519 ng N-nitrosoanabasine (NAB) together with N-nitrosoanatabine (NAT)/cigarette. The amounts of NNN, NNK and NAB/NAT in mainstream smoke were 11-156, 7-73 and 17-146 ng/cigarette, respectively.

摘要

通过气相色谱-热能分析，对不同品牌的印度香烟进行了分析，以检测烟草及主流烟气中致癌性烟草特有N-亚硝胺（TSNA）的存在情况。卷烟烟草中预先形成的TSNA含量为：每支香烟含68至730纳克N-亚硝基去甲烟碱（NNN）、19至174纳克4-（N-亚硝基甲基氨基）-1-（3-吡啶基）-1-丁酮（NNK），以及98至519纳克N-亚硝基新烟草碱（NAB）与N-亚硝基假木贼碱（NAT）。主流烟气中NNN、NNK和NAB/NAT的含量分别为每支香烟11至156纳克、7至73纳克和17至146纳克。