Department of Biomedical Sciences, Carlson College of Veterinary Medicine, Oregon State University, Corvallis, OR, 97331, USA.
Department of Animal and Rangeland Sciences, College of Agricultural Sciences, Oregon State University, Corvallis, OR, 97331, USA; Linus Pauling Institute, Oregon State University, Corvallis, OR, 97331, USA.
J Trace Elem Med Biol. 2018 Dec;50:640-645. doi: 10.1016/j.jtemb.2018.05.014. Epub 2018 May 26.
Intestinal absorption of immunoglobulins is critical for health and survival of newborn calves because there is no transfer of immunoglobulins in utero. The objective of this study was to determine if feeding beef cows Se-enriched alfalfa hay during the last trimester of gestation improves passive transfer of ovalbumin (OVA), a surrogate protein marker for IgG absorption. Control cows (n = 15) were fed non-Se-fortified alfalfa hay (5.3 mg Se/head daily) plus a mineral supplement containing inorganic Se (3 mg Se/head daily). Med-Se (n = 15) and High-Se cows (n = 15) were fed Se-biofortified alfalfa hay (27.6 and 57.5 mg Se/head daily, respectively); both groups received mineral supplement without added Se. Calves were randomly assigned to receive orally administered OVA at 12, 24, or 36 h of age. Calves that received their oral dose of OVA at 12 h of age had higher serum OVA concentrations across the first 48 h of life if born to High-Se cows compared to calves born to Control cows (P = 0.05), with intermediate values for calves born to Med-Se cows. Our results, using OVA as a model for passive transfer, suggest that if calves do not receive adequate colostrum to reach maximum pinocytosis, then supranutritional Se supplementation in beef cattle may improve passive transfer in their calves, if calves receive colostrum within the first 12 h of age.
肠道吸收免疫球蛋白对新生牛犊的健康和存活至关重要，因为在子宫内没有免疫球蛋白的转移。本研究的目的是确定在妊娠的最后三个月给奶牛饲喂富硒苜蓿干草是否能改善卵清蛋白（OVA）的被动转移，OVA 是 IgG 吸收的替代蛋白质标志物。对照组奶牛（n=15）饲喂非富硒苜蓿干草（每天 5.3mg Se/头）加含有无机硒的矿物质补充剂（每天 3mg Se/头）。Med-Se（n=15）和 High-Se 奶牛（n=15）饲喂富硒苜蓿干草（每天分别为 27.6 和 57.5mg Se/头）；两组均接受不含额外硒的矿物质补充剂。犊牛随机接受口服 OVA，在 12、24 或 36 小时龄时给药。在 12 小时龄接受口服 OVA 的犊牛在生命的前 48 小时内血清 OVA 浓度更高，如果它们出生于 High-Se 奶牛，与出生于 Control 奶牛的犊牛相比（P=0.05），出生于 Med-Se 奶牛的犊牛的 OVA 浓度处于中间值。我们使用 OVA 作为被动转移的模型的结果表明，如果犊牛没有获得足够的初乳来达到最大的胞饮作用，那么在肉牛中超营养硒补充可能会改善其犊牛的被动转移，如果犊牛在 12 小时龄内接受初乳。
