Rodrigues Cláudia Medeiros, Parmeggiani Eliana Burtet, Leal Karoline Wagner, Schneider Marla, Collet Silvana Giacomini, Cibin Francielli Weber Santos, Gomes Viviani, Blagitz Maiara Garcia, Rocha João Batista Teixeira da, Leal Marta Lizandra do Rêgo
Department of Large Animal Clinic, Federal University of Santa Maria, Santa Maria 97105-900, RS, Brazil.
Veterinary Medicine Course, Central Education Unit Faem Faculty, Chapecó 89812-214, SC, Brazil.
Animals (Basel). 2023 Dec 19;14(1):10. doi: 10.3390/ani14010010.
This study aimed to assess the impact of prepartum maternal diphenyl diselenide (PhSe) supplementation on the development, biochemical, immune, and antioxidant parameters of calves. Eighteen Holstein breed calves were used, born to females who were or were not subjected to supplementation, at 42, 28, and 14 days prior to calving. The (PhSe) group (DDG) was administered 3 μmol/kg of (PhSe) in 4 mL of dimethyl sulfoxide (DMSO), while the DMSO and NaCl groups were administered 4 mL of DMSO and 0.9% NaCl, subcutaneously. The calves were evaluated based on their weight, withers height, body condition score 24 h post-birth (0), as well on days 14, 28, 42, 56, 70. Blood samples were also taken to determine serum variables. Calves on the DDG showed higher average levels of total protein, albumin, and globulins on day 0, and the immunoglobulin G level was significantly higher than the other groups on days 0, 14, 56, 70. Maternal supplementation showed immunomodulatory effect on calves, evidenced by the exceptional rates of passive immunity transfer, as well as the enhancement of humoral immunity. Our research offers fresh insights into the immunomodulatory potential of (PhSe), making it a viable alternative in facing this challenging phase, rearing dairy calves.
本研究旨在评估产前母体补充二苯基二硒醚（PhSe）对犊牛发育、生化、免疫和抗氧化参数的影响。使用了18头荷斯坦品种的犊牛，它们的母亲在产犊前42天、28天和14天接受或未接受补充剂。（PhSe）组（DDG）皮下注射3 μmol/kg的（PhSe），溶于4 mL二甲基亚砜（DMSO）中，而DMSO组和NaCl组分别皮下注射4 mL DMSO和0.9% NaCl。根据犊牛出生后24小时（0天）、14天、28天、42天、56天和70天的体重、体高和体况评分对其进行评估。还采集血样以测定血清变量。DDG组犊牛在0天时总蛋白、白蛋白和球蛋白的平均水平较高，并且在0天、14天、56天和70天时免疫球蛋白G水平显著高于其他组。母体补充剂对犊牛具有免疫调节作用，这通过被动免疫转移的优异比率以及体液免疫的增强得以证明。我们的研究为（PhSe）的免疫调节潜力提供了新的见解，使其成为饲养奶牛犊牛这一具有挑战性阶段的可行选择。
