Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China.
Sci Rep. 2018 Jun 21;8(1):9453. doi: 10.1038/s41598-018-27896-y.
Whether the dynamic change of neutrophil to lymphocyte ratio (delta-NLR) can predict the outcome in various malignancies remained controversial. The delta-NLR has not been evaluated in colon cancer. Thus, we conducted the study to evaluate the predictive value of the delta-NLR in patients with colon cancer who underwent curative resection. Three-hundred and fifty-four patients with stage I-III colon cancer were retrospectively analysed. Clinicopathological features, preoperative NLR and postoperative NLR were collected. Prognostic factors were evaluated by univariate and multivariate analysis. The one, three and five-year overall survival rate in the delta-NLR < 0 group was 98.2%, 90.7% and 83.6%, respectively; and in the delta-NLR ≥ 0 group was 98.4%, 96.9% and 95.3%, respectively (log-rank test, P = 0.002). Univariate and multivariate analysis showed that there was a strong relationship between delta-NLR and overall survival. In conclusion, the delta-NLR was an independent prognostic factor for overall survival in early stage colon cancer. Patients with increased delta-NLR had an favourable clinical outcome.
中性粒细胞与淋巴细胞比值（delta-NLR）的动态变化是否能预测各种恶性肿瘤的预后仍存在争议。delta-NLR 在结肠癌中尚未得到评估。因此，我们进行了这项研究，以评估 delta-NLR 在接受根治性切除术的结肠癌患者中的预测价值。回顾性分析了 354 例 I-III 期结肠癌患者。收集了临床病理特征、术前 NLR 和术后 NLR。通过单因素和多因素分析评估预后因素。delta-NLR<0 组的 1、3、5 年总生存率分别为 98.2%、90.7%和 83.6%；delta-NLR≥0 组的 1、3、5 年总生存率分别为 98.4%、96.9%和 95.3%（log-rank 检验，P=0.002）。单因素和多因素分析表明，delta-NLR 与总生存率之间存在很强的关系。总之，delta-NLR 是早期结肠癌总生存率的独立预后因素。delta-NLR 升高的患者具有较好的临床结局。
