Thavaramara Thaovalai, Phaloprakarn Chadakarn, Tangjitgamol Siriwan, Manusirivithaya Sumonmal
Department of Obstetrics and Gynecology, Bangkok Metropolitan Administration Medical College and Vajira Hospital, Bangkok, Thailand.
J Med Assoc Thai. 2011 Jul;94(7):871-7.
To determine whether level of preoperative peripheral blood neutrophil to lymphocyte ratio (NLR) was a prognostic indicator for epithelial ovarian cancer (EOC) patient. The present study further aimed to evaluate the impact of the change of preoperative/postoperative NLR on the survival.
Medical records of the patients undergoing an operation for EOC in Vajira Hospital between January 1, 2004 and December 31, 2009 were reviewed. Demographic, clinicopathological, and laboratory data were assessed. Preoperative NLR level was divided into high (more than 2.6) and low (2.6 or less) groups and their association with survival were determined. The survival of the subjects according to their preoperative NLR compared to postoperative level was also evaluated.
Mean age of 129 subjects was 49.6 +/- 12.5 years. Median pre- and post-operative NLR were 2.8 (range 0.86 to 30.0) and 2.7 (range 0.16 to 31.3), respectively. Seventy-one patients (55.0%) had high preoperative NLR and 64 (53.8%) had high postoperative value. High preoperative and pre- and post-operative NLR were significantly associated with advanced stage and suboptimal surgery. While high post-operative NLR was significantly associated with advanced stage but not suboptimal surgery. In univariable analysis, preoperative/postoperative high/high NLR tended to associate with poor progression free survival (PFS) but not overall survival (OS), with p = 0.019 and p = 0.052 respectively. By multivariable analysis, the advanced stage and suboptimal surgery, but not preoperative and postoperative NLR, were independent poor prognostic factors for PFS and OS.
The level of preoperative NLR and the change of preoperative/postoperative NLR level tended to associate with PFS more than OS of EOC patient.
确定术前外周血中性粒细胞与淋巴细胞比值（NLR）水平是否为上皮性卵巢癌（EOC）患者的预后指标。本研究进一步旨在评估术前/术后NLR变化对生存的影响。
回顾了2004年1月1日至2009年12月31日在瓦吉拉医院接受EOC手术患者的病历。评估了人口统计学、临床病理和实验室数据。术前NLR水平分为高（大于2.6）和低（2.6或更低）两组，并确定它们与生存的关联。还评估了受试者根据术前NLR与术后水平的生存情况。
129名受试者的平均年龄为49.6±12.5岁。术前和术后NLR的中位数分别为2.8（范围0.86至30.0）和2.7（范围0.16至31.3）。71名患者（55.0%）术前NLR高，64名患者（53.8%）术后值高。术前高以及术前和术后NLR高与晚期和手术不理想显著相关。而术后NLR高与晚期显著相关，但与手术不理想无关。在单变量分析中，术前/术后高/高NLR倾向于与无进展生存期（PFS）差相关，但与总生存期（OS）无关，p值分别为0.019和0.052。通过多变量分析，晚期和手术不理想，而非术前和术后NLR，是PFS和OS的独立不良预后因素。
术前NLR水平以及术前/术后NLR水平的变化与EOC患者的PFS相关性比与OS的相关性更强。
