Brain Tumor Center, Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Epigenetics Institute, University of Pennsylvania, Philadelphia, PA, USA.
Nat Rev Mol Cell Biol. 2018 Sep;19(9):563-578. doi: 10.1038/s41580-018-0029-7.
Metabolism and gene expression, which are two fundamental biological processes that are essential to all living organisms, reciprocally regulate each other to maintain homeostasis and regulate cell growth, survival and differentiation. Metabolism feeds into the regulation of gene expression via metabolic enzymes and metabolites, which can modulate chromatin directly or indirectly - through regulation of the activity of chromatin trans-acting proteins, including histone-modifying enzymes, chromatin-remodelling complexes and transcription regulators. Deregulation of these metabolic activities has been implicated in human diseases, prominently including cancer.
代谢和基因表达是所有生物生存所必需的两个基本生物过程，它们相互调节以维持体内平衡并调节细胞生长、存活和分化。代谢通过代谢酶和代谢物来调节基因表达，这些物质可以直接或间接调节染色质 - 通过调节染色质转位蛋白的活性，包括组蛋白修饰酶、染色质重塑复合物和转录调节剂。这些代谢活动的失调与人类疾病有关，尤其是癌症。
