代谢酶和代谢产物对染色质和基因表达的调控。
Regulation of chromatin and gene expression by metabolic enzymes and metabolites.
机构信息
Brain Tumor Center, Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Epigenetics Institute, University of Pennsylvania, Philadelphia, PA, USA.
出版信息
Nat Rev Mol Cell Biol. 2018 Sep;19(9):563-578. doi: 10.1038/s41580-018-0029-7.
Abstract
Metabolism and gene expression, which are two fundamental biological processes that are essential to all living organisms, reciprocally regulate each other to maintain homeostasis and regulate cell growth, survival and differentiation. Metabolism feeds into the regulation of gene expression via metabolic enzymes and metabolites, which can modulate chromatin directly or indirectly - through regulation of the activity of chromatin trans-acting proteins, including histone-modifying enzymes, chromatin-remodelling complexes and transcription regulators. Deregulation of these metabolic activities has been implicated in human diseases, prominently including cancer.
摘要
代谢和基因表达是所有生物生存所必需的两个基本生物过程，它们相互调节以维持体内平衡并调节细胞生长、存活和分化。代谢通过代谢酶和代谢物来调节基因表达，这些物质可以直接或间接调节染色质 - 通过调节染色质转位蛋白的活性，包括组蛋白修饰酶、染色质重塑复合物和转录调节剂。这些代谢活动的失调与人类疾病有关，尤其是癌症。
相似文献
1
Regulation of chromatin and gene expression by metabolic enzymes and metabolites.代谢酶和代谢产物对染色质和基因表达的调控。
Nat Rev Mol Cell Biol. 2018 Sep;19(9):563-578. doi: 10.1038/s41580-018-0029-7.
2
Rheostat control of gene expression by metabolites.代谢物对基因表达的变阻器控制。
Mol Cell. 2006 Oct 6;24(1):1-11. doi: 10.1016/j.molcel.2006.09.002.
3
Modifying Chromatin by Histone Tail Clipping.通过组蛋白尾部修剪来修饰染色质。
J Mol Biol. 2018 Sep 14;430(18 Pt B):3051-3067. doi: 10.1016/j.jmb.2018.07.013. Epub 2018 Jul 25.
4
Enhancer function regulated by combinations of transcription factors and cofactors.转录因子和辅助因子组合调控增强子功能。
Genes Cells. 2018 Oct;23(10):808-821. doi: 10.1111/gtc.12634. Epub 2018 Aug 31.
5
Experimental analysis of chromatin function in transcription control.转录调控中染色质功能的实验分析。
Crit Rev Eukaryot Gene Expr. 1994;4(4):403-41.
6
Interplay between chromatin remodelers and protein arginine methyltransferases.染色质重塑因子与蛋白质精氨酸甲基转移酶之间的相互作用。
J Cell Physiol. 2007 Nov;213(2):306-15. doi: 10.1002/jcp.21180.
7
Chromatin crosstalk in development and disease: lessons from REST.发育与疾病中的染色质串扰：来自REST的启示
Nat Rev Genet. 2007 Jul;8(7):544-54. doi: 10.1038/nrg2100.
8
Chromatin and Metabolism.染色质与代谢。
Annu Rev Biochem. 2018 Jun 20;87:27-49. doi: 10.1146/annurev-biochem-062917-012634.
9
Distinct GCN5/PCAF-containing complexes function as co-activators and are involved in transcription factor and global histone acetylation.不同的含GCN5/PCAF复合物作为共激活因子发挥作用，并参与转录因子和整体组蛋白乙酰化过程。
Oncogene. 2007 Aug 13;26(37):5341-57. doi: 10.1038/sj.onc.1210604.
10
The MTG proteins: chromatin repression players with a passion for networking.MTG蛋白：热衷于形成网络的染色质抑制因子。
Genomics. 2004 Jul;84(1):1-9. doi: 10.1016/j.ygeno.2004.02.011.
引用本文的文献
1
Interplay of YEATS2 and GCDH regulates histone crotonylation and drives EMT in head and neck cancer.YEATS2与GCDH的相互作用调节组蛋白巴豆酰化并驱动头颈癌中的上皮-间质转化。
Elife. 2025 Aug 14;14:RP103321. doi: 10.7554/eLife.103321.
2
Protocol for elucidating metabolite binding and regulation of TET2 dioxygenase.阐明TET2双加氧酶的代谢物结合与调控的实验方案。
STAR Protoc. 2025 Aug 6;6(3):104015. doi: 10.1016/j.xpro.2025.104015.
3
Nucleus-translocated glucokinase functions as a protein kinase to phosphorylate TAZ and promote tumour growth.细胞核易位的葡萄糖激酶作为一种蛋白激酶发挥作用，使TAZ磷酸化并促进肿瘤生长。
Nat Commun. 2025 Aug 4;16(1):7156. doi: 10.1038/s41467-025-62566-4.
4
Matrix stiffness boosts PDAC chemoresistance via SCD1-dependent lipid metabolic reprogramming.基质硬度通过SCD1依赖性脂质代谢重编程增强胰腺导管腺癌的化疗耐药性。
Regen Biomater. 2025 Jun 16;12:rbaf056. doi: 10.1093/rb/rbaf056. eCollection 2025.
5
The Fundamental Role of Nutrients for Metabolic Balance and Epigenome Integrity Maintenance.营养素对代谢平衡和表观基因组完整性维持的重要作用。
Epigenomes. 2025 Jul 9;9(3):23. doi: 10.3390/epigenomes9030023.
6
Growth phase diets diminish histone acetyltransferase Gcn5 function and shorten lifespan of Drosophila males.生长期饮食会削弱组蛋白乙酰转移酶Gcn5的功能并缩短雄性果蝇的寿命。
EMBO Rep. 2025 Jul 10. doi: 10.1038/s44319-025-00503-8.
7
Endocrine-disrupting chemicals (EDCs) and epigenetic regulation in embryonic development: Mechanisms, impacts, and emerging trends.内分泌干扰化学物质（EDCs）与胚胎发育中的表观遗传调控：作用机制、影响及新趋势
Toxicol Rep. 2024 Dec 27;14:101885. doi: 10.1016/j.toxrep.2024.101885. eCollection 2025 Jun.
8
A Scoping Review of Epigenetic Signatures of Diet and Diet-related Metabolites: Insights from Epigenome-Wide Association Studies and Their Implications for Cardiometabolic Health and Diseases.饮食及与饮食相关代谢物的表观遗传特征的范围综述：来自全表观基因组关联研究的见解及其对心脏代谢健康和疾病的影响
Yale J Biol Med. 2025 Jun 30;98(2):203-225. doi: 10.59249/BDGN2070. eCollection 2025 Jun.
9
Multi-Cohort Exploration of Repetitive Element Transcription and DNA Methylation in Human Steatotic Liver Disease.人类脂肪性肝病中重复元件转录和DNA甲基化的多队列探索
Int J Mol Sci. 2025 Jun 8;26(12):5494. doi: 10.3390/ijms26125494.
10
High-Specificity Spatiotemporal Cholesterol Detection by Quadrature Phase-Shifted Polarization Stimulated Raman Imaging.通过正交相移偏振激发拉曼成像进行高特异性时空胆固醇检测
Angew Chem Int Ed Engl. 2025 Aug 4;64(32):e202505038. doi: 10.1002/anie.202505038. Epub 2025 Jun 8.
本文引用的文献
1
Metabolic enzyme PFKFB4 activates transcriptional coactivator SRC-3 to drive breast cancer.代谢酶 PFKFB4 激活转录共激活因子 SRC-3 以驱动乳腺癌。
Nature. 2018 Apr;556(7700):249-254. doi: 10.1038/s41586-018-0018-1. Epub 2018 Apr 3.
2
Metabolic Kinases Moonlighting as Protein Kinases.代谢激酶兼职蛋白激酶。
Trends Biochem Sci. 2018 Apr;43(4):301-310. doi: 10.1016/j.tibs.2018.01.006. Epub 2018 Feb 17.
3
KAT2A coupled with the α-KGDH complex acts as a histone H3 succinyltransferase.KAT2A 与 α-KGDH 复合物一起作为组蛋白 H3 琥珀酰转移酶。
Nature. 2017 Dec 14;552(7684):273-277. doi: 10.1038/nature25003. Epub 2017 Dec 6.
4
Spatiotemporal Control of Acetyl-CoA Metabolism in Chromatin Regulation.组蛋白乙酰化调控中的乙酰辅酶 A 代谢的时空控制。
Trends Biochem Sci. 2018 Jan;43(1):61-74. doi: 10.1016/j.tibs.2017.11.004. Epub 2017 Nov 23.
5
Histone propionylation is a mark of active chromatin.组蛋白丙酰化是活性染色质的一种标记。
Nat Struct Mol Biol. 2017 Dec;24(12):1048-1056. doi: 10.1038/nsmb.3490. Epub 2017 Oct 23.
6
Local histone acetylation by ACSS2 promotes gene transcription for lysosomal biogenesis and autophagy.ACSS2 通过局部组蛋白乙酰化促进溶酶体生物发生和自噬的基因转录。
Autophagy. 2017 Oct 3;13(10):1790-1791. doi: 10.1080/15548627.2017.1349581. Epub 2017 Aug 18.
7
Nuclear Acetyl-CoA Production by ACLY Promotes Homologous Recombination.ACLY催化产生的细胞核乙酰辅酶A促进同源重组。
Mol Cell. 2017 Jul 20;67(2):252-265.e6. doi: 10.1016/j.molcel.2017.06.008. Epub 2017 Jul 6.
8
O-GlcNAcylation of fumarase maintains tumour growth under glucose deficiency.乌头酸酶的 O-GlcNAc 修饰在葡萄糖缺乏条件下维持肿瘤生长。
Nat Cell Biol. 2017 Jul;19(7):833-843. doi: 10.1038/ncb3562. Epub 2017 Jun 19.
9
Shaping vulnerability to addiction - the contribution of behavior, neural circuits and molecular mechanisms.塑造成瘾易感性——行为、神经回路和分子机制的贡献。
Neurosci Biobehav Rev. 2018 Feb;85:117-125. doi: 10.1016/j.neubiorev.2017.05.019. Epub 2017 May 29.
10
Acetyl-CoA synthetase regulates histone acetylation and hippocampal memory.乙酰辅酶A合成酶调节组蛋白乙酰化和海马体记忆。
Nature. 2017 Jun 15;546(7658):381-386. doi: 10.1038/nature22405. Epub 2017 May 31.
Zotero 插件