• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

血清淀粉样蛋白 P 成分通过对巨噬细胞的作用治疗性减轻小鼠动脉粥样硬化。

Serum amyloid P component therapeutically attenuates atherosclerosis in mice via its effects on macrophages.

机构信息

Department of Critical Care Medicine, Nanfang Hospital, Southern Medical University, No.1023, South Shatai Road, Baiyun District, Guangzhou, Guangdong, People's Republic of China, 510515.

Department of Cardiology, Huqiao Medical Center, Nanfang Hospital, Southern Medical University, No.1023, South Shatai Road, Baiyun District, Guangzhou, People's Republic of China, 510515.

出版信息

Theranostics. 2018 May 11;8(12):3214-3223. doi: 10.7150/thno.22704. eCollection 2018.

DOI:10.7150/thno.22704
PMID:29930724
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6010983/
Abstract

A hallmark of atherosclerosis is the formation of macrophage-derived foam cells. Serum amyloid P component (SAP), a member of the pentraxin family of proteins, is known to affect macrophage activation. However, the role of SAP in atherosclerosis is still unclear. Apolipoprotein E-deficient (Apoe) mice fed a high-fat diet were given intraperitoneal injections of SAP (6 mg/kg) every other day for a total of 2 weeks to characterize atherosclerosis development. We showed that intraperitoneal injection of SAP attenuated atherosclerosis in Apoe mice. Immunostaining of aortic roots indicated that SAP was up-taken by the lesion area. In SAP-treated mice, serum paraoxonase1 (PON1) activity was increased whereas high-density lipoprotein inflammatory index (HII) was reduced. The cholesterol efflux rate in macrophages was elevated along with the expression of cholesterol efflux proteins. Through bioinformatics analysis followed by experimental validation, we found that proline/serine-rich coiled-coil protein 1 (Psrc1) was an important downstream effector of SAP in macrophages. Our findings reveal an anti-atherosclerotic role of SAP and extend the current knowledge regarding this molecule as a marker for atherosclerosis.

摘要

动脉粥样硬化的一个标志是巨噬细胞衍生的泡沫细胞的形成。血清淀粉样蛋白 P 成分（SAP）是五聚蛋白家族的成员之一，已知其会影响巨噬细胞的激活。然而，SAP 在动脉粥样硬化中的作用仍不清楚。用高脂肪饮食喂养载脂蛋白 E 缺陷（Apoe）小鼠，每隔一天腹膜内注射 SAP（6mg/kg），共 2 周，以表征动脉粥样硬化的发展。我们发现 SAP 腹膜内注射可减轻 Apoe 小鼠的动脉粥样硬化。主动脉根部免疫染色表明 SAP 被病变区域摄取。在 SAP 处理的小鼠中，血清对氧磷酶 1（PON1）活性增加，而高密度脂蛋白炎症指数（HII）降低。巨噬细胞中的胆固醇流出率升高，同时胆固醇流出蛋白的表达也升高。通过生物信息学分析和实验验证，我们发现脯氨酸/丝氨酸丰富卷曲螺旋蛋白 1（Psrc1）是 SAP 在巨噬细胞中的一个重要下游效应因子。我们的研究结果揭示了 SAP 的抗动脉粥样硬化作用，并扩展了该分子作为动脉粥样硬化标志物的现有知识。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/05ec/6010983/31148cd02580/thnov08p3214g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/05ec/6010983/67c335346072/thnov08p3214g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/05ec/6010983/ff0799c58215/thnov08p3214g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/05ec/6010983/295f74b5504a/thnov08p3214g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/05ec/6010983/59ec31f3c9ed/thnov08p3214g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/05ec/6010983/31148cd02580/thnov08p3214g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/05ec/6010983/67c335346072/thnov08p3214g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/05ec/6010983/ff0799c58215/thnov08p3214g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/05ec/6010983/295f74b5504a/thnov08p3214g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/05ec/6010983/59ec31f3c9ed/thnov08p3214g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/05ec/6010983/31148cd02580/thnov08p3214g005.jpg

相似文献

1
Serum amyloid P component therapeutically attenuates atherosclerosis in mice via its effects on macrophages.血清淀粉样蛋白 P 成分通过对巨噬细胞的作用治疗性减轻小鼠动脉粥样硬化。
Theranostics. 2018 May 11;8(12):3214-3223. doi: 10.7150/thno.22704. eCollection 2018.
2
SAP deficiency mitigated atherosclerotic lesions in ApoE(-/-) mice.SAP缺乏减轻了ApoE(-/-)小鼠的动脉粥样硬化病变。
Atherosclerosis. 2016 Jan;244:179-87. doi: 10.1016/j.atherosclerosis.2015.11.009. Epub 2015 Nov 23.
3
PSRC1 overexpression attenuates atherosclerosis progression in apoE mice by modulating cholesterol transportation and inflammation.PSRC1 过表达通过调节胆固醇转运和炎症来减轻 apoE 小鼠的动脉粥样硬化进展。
J Mol Cell Cardiol. 2018 Mar;116:69-80. doi: 10.1016/j.yjmcc.2018.01.013. Epub 2018 Feb 3.
4
Serum amyloid P attenuates M2 macrophage activation and protects against fungal spore-induced allergic airway disease.血清淀粉样蛋白 P 可减轻 M2 型巨噬细胞的活化，并可预防真菌孢子诱导的过敏性气道疾病。
J Allergy Clin Immunol. 2010 Oct;126(4):712-721.e7. doi: 10.1016/j.jaci.2010.06.010. Epub 2010 Jul 31.
5
A novel small molecule liver X receptor transcriptional regulator, nagilactone B, suppresses atherosclerosis in apoE-deficient mice.一种新型小分子肝 X 受体转录调节剂，那格列酮 B，可抑制载脂蛋白 E 缺陷小鼠的动脉粥样硬化。
Cardiovasc Res. 2016 Oct;112(1):502-14. doi: 10.1093/cvr/cvw183. Epub 2016 Jul 26.
6
Kuwanon G attenuates atherosclerosis by upregulation of LXRα-ABCA1/ABCG1 and inhibition of NFκB activity in macrophages.库瓦诺因 G 通过上调巨噬细胞中的 LXRα-ABCA1/ABCG1 和抑制 NFκB 活性来减轻动脉粥样硬化。
Toxicol Appl Pharmacol. 2018 Feb 15;341:56-63. doi: 10.1016/j.taap.2018.01.007. Epub 2018 Feb 2.
7
Apolipoprotein A-I protection against atherosclerosis is dependent on genetic background.载脂蛋白 A-I 对动脉粥样硬化的保护作用依赖于遗传背景。
Arterioscler Thromb Vasc Biol. 2014 Feb;34(2):262-9. doi: 10.1161/ATVBAHA.113.302831. Epub 2013 Dec 12.
8
G004, a synthetic sulfonylurea compound, exerts anti-atherosclerosis effects by targeting SIRT1 in ApoE mice.G004是一种合成磺脲类化合物，通过作用于载脂蛋白E（ApoE）小鼠体内的沉默信息调节因子1（SIRT1）发挥抗动脉粥样硬化作用。
Vascul Pharmacol. 2017 Feb;89:49-57. doi: 10.1016/j.vph.2016.12.003. Epub 2017 Jan 6.
9
Attenuation of early atherogenesis in low-density lipoprotein receptor-deficient mice by proteasome inhibition.蛋白酶体抑制作用可减轻低密度脂蛋白受体缺陷型小鼠早期动脉粥样硬化形成。
Arterioscler Thromb Vasc Biol. 2012 Jun;32(6):1418-26. doi: 10.1161/ATVBAHA.112.249342. Epub 2012 Apr 19.
10
Medium-chain triglycerides promote macrophage reverse cholesterol transport and improve atherosclerosis in ApoE-deficient mice fed a high-fat diet.中链甘油三酯可促进巨噬细胞的胆固醇逆向转运，并改善高脂饮食喂养的载脂蛋白E缺陷小鼠的动脉粥样硬化。
Nutr Res. 2016 Sep;36(9):964-973. doi: 10.1016/j.nutres.2016.06.004. Epub 2016 Jun 4.

引用本文的文献

1
Proteomic analysis of carotid artery plaques with and without vulnerable features on magnetic resonance angiography with vessel wall imaging: a pilot study.基于磁共振血管造影血管壁成像的具有和不具有易损特征的颈动脉斑块的蛋白质组学分析：一项初步研究。
JVS Vasc Sci. 2025 Jan 21;6:100281. doi: 10.1016/j.jvssci.2025.100281. eCollection 2025.
2
Potential plasma biomarkers at low altitude for prediction of acute mountain sickness.低海拔地区预测急性高原病的潜在血浆生物标志物。
Front Immunol. 2023 Sep 28;14:1237465. doi: 10.3389/fimmu.2023.1237465. eCollection 2023.
3
The prognostic capability of inflammatory proteins in predicting peripheral artery disease related adverse events.

本文引用的文献

1
Dynamin-Related Protein 1 Inhibition Attenuates Cardiovascular Calcification in the Presence of Oxidative Stress.动力相关蛋白1抑制在氧化应激存在时减轻心血管钙化。
Circ Res. 2017 Jul 21;121(3):220-233. doi: 10.1161/CIRCRESAHA.116.310293. Epub 2017 Jun 12.
2
A genetic risk score is significantly associated with statin therapy response in the elderly population.遗传风险评分与老年人群的他汀类药物治疗反应显著相关。
Clin Genet. 2017 Mar;91(3):379-385. doi: 10.1111/cge.12890. Epub 2016 Dec 12.
3
CD68/macrosialin: not just a histochemical marker.
炎症蛋白预测外周动脉疾病相关不良事件的预后能力。
Front Cardiovasc Med. 2022 Dec 13;9:1073751. doi: 10.3389/fcvm.2022.1073751. eCollection 2022.
4
Functional Characterization of Serum Amyloid P Component (SAP) in Host Defense against Bacterial Infection in a Primary Vertebrate.血清淀粉样蛋白 P 成分（SAP）在初级脊椎动物宿主防御细菌感染中的功能特征。
Int J Mol Sci. 2022 Aug 22;23(16):9468. doi: 10.3390/ijms23169468.
5
Plasma proteomics reveals crosstalk between lipid metabolism and immunity in dairy cows receiving essential fatty acids and conjugated linoleic acid.血浆蛋白质组学揭示了接受必需脂肪酸和共轭亚油酸的奶牛中脂质代谢与免疫之间的相互作用。
Sci Rep. 2022 Apr 5;12(1):5648. doi: 10.1038/s41598-022-09437-w.
6
Decreased Iron Ion Concentrations in the Peripheral Blood Correlate with Coronary Atherosclerosis.外周血铁离子浓度降低与冠状动脉粥样硬化相关。
Nutrients. 2022 Jan 13;14(2):319. doi: 10.3390/nu14020319.
7
Proteomic Studies of Blood and Vascular Wall in Atherosclerosis.动脉粥样硬化中血液和血管壁的蛋白质组学研究。
Int J Mol Sci. 2021 Dec 9;22(24):13267. doi: 10.3390/ijms222413267.
8
Effect of renal function on high-density lipoprotein particles in patients with coronary heart disease.肾功能对冠心病患者高密度脂蛋白颗粒的影响。
BMC Cardiovasc Disord. 2021 Nov 12;21(1):534. doi: 10.1186/s12872-021-02354-2.
9
A CD209 ligand and a sialidase inhibitor differentially modulate adipose tissue and liver macrophage populations and steatosis in mice on the Methionine and Choline-Deficient (MCD) diet.CD209 配体和唾液酸酶抑制剂在蛋氨酸和胆碱缺乏（MCD）饮食的小鼠中差异调节脂肪组织和肝脏巨噬细胞群和脂肪变性。
PLoS One. 2020 Dec 30;15(12):e0244762. doi: 10.1371/journal.pone.0244762. eCollection 2020.
10
Endothelial to mesenchymal transition contributes to nicotine-induced atherosclerosis.内皮细胞向间充质细胞转化有助于尼古丁诱导的动脉粥样硬化。
Theranostics. 2020 Apr 6;10(12):5276-5289. doi: 10.7150/thno.42470. eCollection 2020.
CD68/巨唾液酸蛋白：不仅仅是一种组织化学标志物。
Lab Invest. 2017 Jan;97(1):4-13. doi: 10.1038/labinvest.2016.116. Epub 2016 Nov 21.
4
The Impact of Serum Amyloid P-Component on Gene Expression in RAW264.7 Mouse Macrophages.血清淀粉样蛋白 P 成分对 RAW264.7 小鼠巨噬细胞基因表达的影响。
Biomed Res Int. 2016;2016:9380290. doi: 10.1155/2016/9380290. Epub 2016 Apr 28.
5
Recombinant human pentraxin-2 therapy in patients with idiopathic pulmonary fibrosis: safety, pharmacokinetics and exploratory efficacy.重组人五聚素-2治疗特发性肺纤维化患者：安全性、药代动力学及探索性疗效
Eur Respir J. 2016 Mar;47(3):889-97. doi: 10.1183/13993003.00850-2015. Epub 2016 Feb 11.
6
SAP: structure, function, and its roles in immune-related diseases.血清淀粉样蛋白P：结构、功能及其在免疫相关疾病中的作用。
Int J Cardiol. 2015;187:20-6. doi: 10.1016/j.ijcard.2015.03.179. Epub 2015 Mar 20.
7
Association of six genetic variants with myocardial infarction.六个基因变异与心肌梗死的关联。
Int J Mol Med. 2015 May;35(5):1451-9. doi: 10.3892/ijmm.2015.2115. Epub 2015 Feb 27.
8
Detection of high-risk atherosclerotic plaques with ultrasound molecular imaging of glycoprotein IIb/IIIa receptor on activated platelets.通过对活化血小板上糖蛋白IIb/IIIa受体进行超声分子成像检测高危动脉粥样硬化斑块。
Theranostics. 2015 Feb 5;5(4):418-30. doi: 10.7150/thno.10020. eCollection 2015.
9
Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins.低密度脂蛋白胆固醇对他汀类药物反应的全基因组关联研究的药物遗传学荟萃分析。
Nat Commun. 2014 Oct 28;5:5068. doi: 10.1038/ncomms6068.
10
Serum amyloid P: a systemic regulator of the innate immune response.血清淀粉样蛋白P：天然免疫反应的系统性调节因子。
J Leukoc Biol. 2014 Nov;96(5):739-43. doi: 10.1189/jlb.1MR0114-068R. Epub 2014 May 7.