Ansari Behnaz, Basiri Keivan, Derakhshan Yeganeh, Kadkhodaei Farzaneh, Okhovat Ali Asghar
Isfahan Neurosciences Research Center, Alzahra Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Neurology, Isfahan University of Medical Sciences, Isfahan, Iran.
Adv Biomed Res. 2018 May 29;7:87. doi: 10.4103/abr.abr_50_17. eCollection 2018.
Guillain-Barre syndrome (GBS) is an immune-mediated peripheral neuropathy. We compared clinical, laboratory characteristics, and disease course of GBS subtypes in a large group of Iranian patients in Isfahan.
We collected data from patients who were admitted to Alzahra referral university Hospital, Isfahan, Iran with a diagnosis of GBS. In this population-based cross-sectional research, characteristic of 388 cases with GBS between 2010 and 2015 were studied.
The current study recruited 388 patients with GBS including 241 males (62.1%) and 147 females (37.9%) with a mean age of 42.78 ± 21.34. Patients with polyradiculopathy had the highest mean age of 55.12 ± 20.59 years, whereas the least age was seen in acute motor axonal neuropathy (AMAN) with the mean of 36.30 ± 18.71 years. The frequency of GBS witnessed the highest frequency in spring with 113 cases (29.1%) and winter with 101 cases (26%). Patients' electrodiagnostic findings indicated that the highest frequency pertained to AMSAN with 93 cases (24%), whereas the least frequent diagnosis was acute Polyradiculopathy with 8 cases (2.1%). Most of the patients did not have any infections (53.6%) and among patients with infections, AMSAN had the highest frequency (22.9%) and finally, patients with AMSAN and AMAN had a higher length of stay.
The study demonstrated incidence, sex distribution, preceding infection, and surgery similar to previous studies. However, our data differs from a study in Tehran that showed acute inflammatory demyelinating polyradiculoneuropathy is more prevalent than other types and we found a seasonal preponderance in cold months, particularly in axonal types.
吉兰-巴雷综合征（GBS）是一种免疫介导的周围神经病。我们比较了伊朗伊斯法罕一大群患者中GBS各亚型的临床、实验室特征及病程。
我们收集了伊朗伊斯法罕阿尔扎赫拉转诊大学医院收治的诊断为GBS的患者的数据。在这项基于人群的横断面研究中，对2010年至2015年间388例GBS患者的特征进行了研究。
本研究纳入了388例GBS患者，其中男性241例（62.1%），女性147例（37.9%），平均年龄42.78±21.34岁。多神经根病患者的平均年龄最高，为55.12±20.59岁，而急性运动轴索性神经病（AMAN）患者的年龄最小，平均为36.30±18.71岁。GBS的发病频率在春季最高，有113例（29.1%），冬季有101例（26%）。患者的电诊断结果表明，最高频率属于急性运动感觉轴索性神经病（AMSAN），有93例（24%），而最少见的诊断是急性多神经根病，有8例（2.1%）。大多数患者没有任何感染（53.6%），在有感染的患者中，AMSAN的频率最高（22.9%），最后，AMSAN和AMAN患者的住院时间更长。
该研究显示的发病率、性别分布、前驱感染及手术情况与以往研究相似。然而，我们的数据与德黑兰的一项研究不同，该研究显示急性炎症性脱髓鞘性多神经根神经病比其他类型更普遍，而我们发现寒冷月份有季节性优势，尤其是轴索性类型。
