阿托伐他汀对难治性强迫症（附加治疗）强迫症状的影响
The Effect of Atorvastatin on Obsessive-compulsive Symptoms of Refractory Obsessive-compulsive Disorder (Add-on Therapy).
作者信息
Akouchekian Shahla, Omranifard Victoria, Moshfegh Parivash, Maracy Mohammad Reza, Almasi Asiyeh
机构信息
Behavioral Sciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Psychosomatic Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
出版信息
Adv Biomed Res. 2018 May 29;7:90. doi: 10.4103/abr.abr_114_16. eCollection 2018.
BACKGROUND
Considering the effect of statins on the regulation of dopamine neurotransmitters and glutamates and importance of the treatment of obsessive-compulsive disorder (OCD) due to its relatively high prevalence and disability of available drugs in treatment of many patients, we came to the point to examine effectiveness of statins in patients with OCD.
MATERIALS AND METHODS
This study is a double-blind randomized clinical trial, which is done in OCD clinic of Isfahan Shariati in 2014 for 1 year. The target population consists of 64 patients with OCD; one group is given a daily 40 mg atorvastatin tablets and the other group receives placebo. At baseline, 4- and 8-week severities of obsessive-compulsive symptoms are measured using Yale-Brown scale and compared in the two groups.
RESULTS
The study results show a statistically significant difference between the two groups of intervention and control ( < 0.001). Furthermore, the results show the intervention effect at the end of the 4 week and 8 week ( < 0.001) that this change is evident in the 4 week but remained almost constant in the 8 week.
CONCLUSION
Overall, the evidences obtained from the study declare the effects of adding statins to treat obsessive-compulsive symptoms.
背景
考虑到他汀类药物对多巴胺神经递质和谷氨酸的调节作用，以及强迫症（OCD）的治疗意义（因其患病率相对较高且现有药物在治疗许多患者时存在缺陷），我们着手研究他汀类药物对强迫症患者的疗效。
材料与方法
本研究为双盲随机临床试验，于2014年在伊斯法罕沙里亚蒂强迫症诊所进行，为期1年。目标人群为64例强迫症患者；一组每天服用40毫克阿托伐他汀片，另一组接受安慰剂。在基线、第4周和第8周时，使用耶鲁-布朗量表测量强迫症状的严重程度，并在两组之间进行比较。
结果
研究结果显示，干预组和对照组之间存在统计学上的显著差异（<0.001）。此外，结果显示在第4周和第8周结束时存在干预效果（<0.001），这种变化在第4周时明显，但在第8周时几乎保持不变。
结论
总体而言，该研究获得的证据表明添加他汀类药物对治疗强迫症状有效。
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