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茶碱对布氏锥虫分化的影响。

Effect of theophylline on differentiation of Trypanosoma brucei.

作者信息

Reed S L, Fierer A S, Goddard D R, Colmerauer M E, Davis C E

出版信息

Infect Immun. 1985 Sep;49(3):844-7. doi: 10.1128/iai.49.3.844-847.1985.

DOI:10.1128/iai.49.3.844-847.1985
PMID:2993168
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC261294/
Abstract

Differentiation of Trypanosoma brucei in the mammal limits the degree of parasitemia and prepares the trypanosome for passage back into the tsetse fly. In an attempt to define the signals that control differentiation, we found that theophylline, in contrast to indomethacin, blocked differentiation, prolonged parasitemia, elevated prostaglandin and cyclic AMP concentrations of rat plasma, and depressed intratrypanosomal cyclic AMP. Relatively nontoxic drugs that alter differentiation are powerful tools for elucidating the events that control this important process.

摘要

布氏锥虫在哺乳动物体内的分化限制了寄生虫血症的程度，并使锥虫为重新进入采采蝇做好准备。为了确定控制分化的信号，我们发现，与吲哚美辛相反，茶碱会阻断分化、延长寄生虫血症、提高大鼠血浆中前列腺素和环磷酸腺苷的浓度，并降低锥虫体内的环磷酸腺苷。改变分化的相对无毒药物是阐明控制这一重要过程的事件的有力工具。

相似文献

1
Effect of theophylline on differentiation of Trypanosoma brucei.茶碱对布氏锥虫分化的影响。
Infect Immun. 1985 Sep;49(3):844-7. doi: 10.1128/iai.49.3.844-847.1985.
2
Indomethacin promotes differentiation of Trypanosoma brucei.吲哚美辛促进布氏锥虫的分化。
Infect Immun. 1984 Jan;43(1):445-8. doi: 10.1128/iai.43.1.445-448.1984.
3
Cyclic 3',5'-adenosine monophosphate levels during the developmental cycle of Trypanosoma brucei brucei in the rat.布氏布氏锥虫在大鼠体内发育周期中的环磷酸腺苷水平
Mol Biochem Parasitol. 1981 May;3(1):19-31. doi: 10.1016/0166-6851(81)90074-8.
4
Endogenous prostaglandins, adenosine 3':5'-monophosphate and sodium transport across isolated frog skin.内源性前列腺素、腺苷3':5'-单磷酸与蛙离体皮肤的钠转运
J Physiol. 1976 Jul;258(3):731-53. doi: 10.1113/jphysiol.1976.sp011443.
5
Preventive effects of theophylline on anaphylactic shock in rats.
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6
Recirculation of Trypanosoma brucei brucei in cattle after T. congolense challenge by tsetse flies.冈比亚锥虫经采采蝇感染牛后布氏布氏锥虫在牛体内的再循环
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Effect of indomethacin on the renal actions of theophylline.吲哚美辛对茶碱肾脏作用的影响。
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8
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The trypanocidal effect of Cannabis sativa constituents in experimental animal trypanosomiasis.大麻成分在实验性动物锥虫病中的杀锥虫作用。
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引用本文的文献

1
cAMP signalling in trypanosomatids: role in pathogenesis and as a drug target.锥虫中的环磷酸腺苷（cAMP）信号传导：在发病机制中的作用及作为药物靶点
Trends Parasitol. 2015 Aug;31(8):373-9. doi: 10.1016/j.pt.2015.04.014. Epub 2015 May 21.
2
Cloning and characterization of a cAMP-specific phosphodiesterase (TbPDE2B) from Trypanosoma brucei.布氏锥虫cAMP特异性磷酸二酯酶（TbPDE2B）的克隆与特性分析
Proc Natl Acad Sci U S A. 2002 Apr 2;99(7):4714-9. doi: 10.1073/pnas.002031599.
3
The trypanosome surface glycoprotein procyclin is expressed only on tsetse fly vector stages of the parasite.锥虫表面糖蛋白前环素仅在寄生虫的采采蝇载体阶段表达。
Parasitol Res. 1989;76(2):171-3. doi: 10.1007/BF00930841.
4
The trypanosome leucine repeat gene in the variant surface glycoprotein expression site encodes a putative metal-binding domain and a region resembling protein-binding domains of yeast, Drosophila, and mammalian proteins.可变表面糖蛋白表达位点中的锥虫亮氨酸重复基因编码一个推定的金属结合结构域和一个类似于酵母、果蝇及哺乳动物蛋白质的蛋白质结合结构域的区域。
Mol Cell Biol. 1990 Dec;10(12):6436-44. doi: 10.1128/mcb.10.12.6436-6444.1990.
5
A gene from the variant surface glycoprotein expression site encodes one of several transmembrane adenylate cyclases located on the flagellum of Trypanosoma brucei.来自可变表面糖蛋白表达位点的一个基因编码布氏锥虫鞭毛上几种跨膜腺苷酸环化酶之一。
Mol Cell Biol. 1992 Mar;12(3):1218-25. doi: 10.1128/mcb.12.3.1218-1225.1992.

本文引用的文献

1
Adenosine 3',5'-phosphate in biological materials. I. Purification and properties of cyclic 3',5'-nucleotide phosphodiesterase and use of this enzyme to characterize adenosine 3',5'-phosphate in human urine.生物材料中的3',5'-磷酸腺苷。I. 环3',5'-核苷酸磷酸二酯酶的纯化及性质，以及用该酶鉴定人尿中的3',5'-磷酸腺苷
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Factors that may influence the infection rate of Glossina palpalis with Trypanosoma gambiense. II. The number and morphology of the trypano-somes present in the blood of the host at the time of the infected feed.可能影响冈比亚按蚊感染冈比亚锥虫感染率的因素。II. 受感染进食时宿主血液中存在的锥虫数量和形态。
Ann Trop Med Parasitol. 1960 Oct;54:341-50.
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The polymorphism of Trypanosoma brucei and T. rhodesiense, its relation to relapses and remissions of infections in white rats, and the effect of cortisone.布氏锥虫和罗德西亚锥虫的多态性、其与白鼠感染复发和缓解的关系以及可的松的作用。
Ann Trop Med Parasitol. 1957 Sep;51(3):301-12. doi: 10.1080/00034983.1957.11685819.
4
Humoral responses against Trypanosoma brucei variable surface antigen are induced by degenerating parasites.针对布氏锥虫可变表面抗原的体液免疫反应是由退化的寄生虫诱导产生的。
Parasite Immunol. 1982 Jul;4(4):245-57. doi: 10.1111/j.1365-3024.1982.tb00436.x.
5
Characteristics of the calcium-mediated mechanism activating adenylate cyclase in Trypanosoma brucei.布氏锥虫中激活腺苷酸环化酶的钙介导机制的特征
Eur J Biochem. 1981 Jun 1;116(3):471-7. doi: 10.1111/j.1432-1033.1981.tb05360.x.
6
Regulation of the growth and differentiation of Trypanosoma (Trypanozoon) brucei brucei in resistant (C57Bl/6) and susceptible (C3H/He) mice.布氏锥虫（布氏锥虫属）在抗性（C57Bl/6）和易感（C3H/He）小鼠体内的生长与分化调控
Parasite Immunol. 1983 Sep;5(5):465-78. doi: 10.1111/j.1365-3024.1983.tb00761.x.
7
Dissociation of effects of xanthine analogs on renal prostaglandins and renal excretory function in the awake rat.黄嘌呤类似物对清醒大鼠肾前列腺素及肾排泄功能影响的解离
J Pharmacol Exp Ther. 1983 Dec;227(3):600-4.
8
Cyclic 3',5'-adenosine monophosphate levels during the developmental cycle of Trypanosoma brucei brucei in the rat.布氏布氏锥虫在大鼠体内发育周期中的环磷酸腺苷水平
Mol Biochem Parasitol. 1981 May;3(1):19-31. doi: 10.1016/0166-6851(81)90074-8.
9
cAMP phosphodiesterase and activator protein of mammalian cAMP phosphodiesterase from Trypanosoma cruzi.来自克氏锥虫的哺乳动物环磷酸腺苷磷酸二酯酶的环磷酸腺苷磷酸二酯酶和激活蛋白。
Mol Biochem Parasitol. 1980 Apr;1(2):107-18. doi: 10.1016/0166-6851(80)90005-5.
10
Inhibition of prostacyclin synthesis in endothelial cells by methylisobutylxanthine is not mediated through elevated cAMP level.甲基异丁基黄嘌呤对内皮细胞中前列环素合成的抑制作用并非通过升高环磷酸腺苷（cAMP）水平介导的。
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