大麻成分在实验性动物锥虫病中的杀锥虫作用。
The trypanocidal effect of Cannabis sativa constituents in experimental animal trypanosomiasis.
作者信息
Nok A J, Ibrahim S, Arowosafe S, Longdet I, Ambrose A, Onyenekwe P C, Whong C Z
机构信息
Department of Biochemistry, Ahmadu Bello University, Zaria-Nigeria.
出版信息
Vet Hum Toxicol. 1994 Dec;36(6):522-4.
PMID:7900270
Abstract
The effect of Cannabis sativa on trypanosome-infected rats was examined. An aqueous extract of the seeds administered at a dose of 50 mg/kg/d cured animals infected with Trypanosome brucei brucei of blood stream parasites. Six fractions eluted from the crude extract by column chromatography were assessed for trypanocidal properties. Of these, only 2 fractions retained trypanocidal activity by curing mice infected with T brucei brucei.
摘要
研究了大麻对感染锥虫的大鼠的影响。以50毫克/千克/天的剂量给予种子水提取物，可治愈感染布氏布氏锥虫血流寄生虫的动物。对通过柱色谱从粗提取物中洗脱的六个馏分进行了杀锥虫特性评估。其中，只有2个馏分通过治愈感染布氏布氏锥虫的小鼠而保留了杀锥虫活性。
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