He Shuli, Zhang Hongwang, Liu Yihao, Sun Fan, Yu Xiang, Li Xueyan, Zhang Li, Wang Lichen, Mao Keya, Wang Gangshi, Lin Yunjuan, Han Zhenchuan, Sabirianov Renat, Zeng Hao
Department of Physics, Capital Normal University, Beijing, 10048, China.
Department of Physics, University at Buffalo, SUNY, Buffalo, NY, 14260, USA.
Small. 2018 Jun 21:e1800135. doi: 10.1002/smll.201800135.
Maximized specific loss power and intrinsic loss power approaching theoretical limits for alternating-current (AC) magnetic-field heating of nanoparticles are reported. This is achieved by engineering the effective magnetic anisotropy barrier of nanoparticles via alloying of hard and soft ferrites. 22 nm Co Mn Fe O /SiO nanoparticles reach a specific loss power value of 3417 W g at a field of 33 kA m and 380 kHz. Biocompatible Zn Fe O /SiO nanoparticles achieve specific loss power of 500 W g and intrinsic loss power of 26.8 nHm kg at field parameters of 7 kA m and 380 kHz, below the clinical safety limit. Magnetic bone cement achieves heating adequate for bone tumor hyperthermia, incorporating an ultralow dosage of just 1 wt% of nanoparticles. In cellular hyperthermia experiments, these nanoparticles demonstrate high cell death rate at low field parameters. Zn Fe O /SiO nanoparticles show cell viabilities above 97% at concentrations up to 500 µg mL within 48 h, suggesting toxicity lower than that of magnetite.
报道了纳米颗粒交流（AC）磁场加热的比损耗功率最大化以及本征损耗功率接近理论极限的情况。这是通过硬磁和软磁铁氧体合金化来设计纳米颗粒的有效磁各向异性势垒实现的。22纳米的CoMnFeO/SiO纳米颗粒在33 kA/m的磁场和380 kHz频率下达到了3417 W/g的比损耗功率值。生物相容性的ZnFeO/SiO纳米颗粒在7 kA/m的磁场参数和380 kHz频率下实现了500 W/g的比损耗功率以及26.8 nHm/kg的本征损耗功率，低于临床安全极限。磁性骨水泥仅包含1 wt%的超低剂量纳米颗粒，就能实现足以用于骨肿瘤热疗的加热效果。在细胞热疗实验中，这些纳米颗粒在低场参数下显示出高细胞死亡率。ZnFeO/SiO纳米颗粒在浓度高达500 μg/mL且48小时内细胞活力高于97%，表明其毒性低于磁铁矿。
