Gonçalves Joana, Nunes Cláudia, Ferreira Liliana, Cruz Maria Margarida, Oliveira Helena, Bastos Verónica, Mayoral Álvaro, Zhang Qing, Ferreira Paula
CICECO-Aveiro Institute of Materials, Department of Materials and Ceramic Engineering, University of Aveiro, 3810-193 Aveiro, Portugal.
Physics Department, University of Coimbra, 3004-516 Coimbra, Portugal.
Nanomaterials (Basel). 2021 Nov 2;11(11):2939. doi: 10.3390/nano11112939.
Magnetic nanoparticles (NP), such as magnetite, have been the subject of research for application in the biomedical field, especially in Magnetic Hyperthermia Therapy (MHT), a promising technique for cancer therapy. NP are often coated with different compounds such as natural or synthetic polymers to protect them from oxidation and enhance their colloidal electrostatic stability while maintaining their thermal efficiency. In this work, the synthesis and characterization of magnetite nanoparticles coated with fucoidan, a biopolymer with recognized biocompatibility and antitumoral activity, is reported. The potential application of NP in MHT was evaluated through the assessment of Specific Loss Power (SLP) under an electromagnetic field amplitude of 14.7 kA m and at 276 kHz. For fucoidan-coated NP, it was obtained SLP values of 100 and 156 W/g, corresponding to an Intrinsic Loss Power (ILP) of 1.7 and 2.6 nHmkg, respectively. These values are, in general, higher than the ones reported in the literature for non-coated magnetite NP or coated with other polymers. Furthermore, in vitro assays showed that fucoidan and fucoidan-coated NP are biocompatible. The particle size (between ca. 6 to 12 nm), heating efficiency, and biocompatibility of fucoidan-coated magnetite NP meet the required criteria for MHT application.
磁性纳米颗粒（NP），如磁铁矿，一直是生物医学领域应用研究的主题，尤其是在磁热疗（MHT）中，这是一种很有前景的癌症治疗技术。NP通常会被不同的化合物包覆，如天然或合成聚合物，以保护它们不被氧化，并在保持其热效率的同时增强其胶体静电稳定性。在这项工作中，报告了用岩藻依聚糖包覆的磁铁矿纳米颗粒的合成与表征，岩藻依聚糖是一种具有公认生物相容性和抗肿瘤活性的生物聚合物。通过在14.7 kA/m的电磁场振幅和276 kHz频率下评估比损耗功率（SLP），对NP在MHT中的潜在应用进行了评估。对于岩藻依聚糖包覆的NP，获得的SLP值分别为100和156 W/g，对应的固有损耗功率（ILP）分别为1.7和2.6 nHm/kg。总体而言，这些值高于文献中报道的未包覆或包覆其他聚合物的磁铁矿NP的值。此外，体外试验表明岩藻依聚糖和岩藻依聚糖包覆的NP具有生物相容性。岩藻依聚糖包覆的磁铁矿NP的粒径（约6至12 nm）、加热效率和生物相容性符合MHT应用的要求标准。
