氯喹和纳米药物递送：一种有前途的组合。
Chloroquine and nanoparticle drug delivery: A promising combination.
机构信息
Department of Transplantation, Mayo Clinic, Jacksonville, FL 32224, USA; Florida State University, Tallahassee, FL 32306, USA.
Department of Transplantation, Mayo Clinic, Jacksonville, FL 32224, USA; Department of Molecular and Translational Medicine, University of Brescia, Brescia 25133, Italy.
出版信息
Pharmacol Ther. 2018 Nov;191:43-49. doi: 10.1016/j.pharmthera.2018.06.007. Epub 2018 Jun 20.
Clinically approved cancer therapies include small molecules, antibodies, and nanoparticles. There has been major progress in the treatment of several cancer types over recent decades. However, many challenges remain for optimal use of conventional and nanoparticle-based therapies in oncology including poor drug delivery, rapid clearance, and drug resistance. The antimalarial agent chloroquine has been found to mitigate some of these challenges by modulating cancer cells and the tissue microenvironment. Particularly, chloroquine was recently found to reduce immunological clearance of nanoparticles by resident macrophages in the liver, leading to increased tumor accumulation of nanodrugs. Additionally, chloroquine has been shown to improve drug delivery and efficacy through normalization of tumor vasculature and suppression of several oncogenic and stress-tolerance pathways, such as autophagy, that protect cancer cells from cytotoxic agents. This review will discuss the use of chloroquine as combination therapy to improve cancer treatment.
临床上批准的癌症疗法包括小分子、抗体和纳米颗粒。近几十年来，几种癌症类型的治疗取得了重大进展。然而，在肿瘤学中优化使用传统和基于纳米颗粒的疗法仍然存在许多挑战，包括药物递送不良、快速清除和耐药性。抗疟药物氯喹被发现通过调节癌细胞和组织微环境来减轻其中的一些挑战。特别是，最近发现氯喹可以减少驻留在肝脏中的巨噬细胞对纳米颗粒的免疫清除，从而导致纳米药物在肿瘤中的积累增加。此外，氯喹已被证明通过正常化肿瘤血管和抑制几种致癌和应激耐受途径（如自噬）来改善药物递送和疗效，这些途径可保护癌细胞免受细胞毒性药物的侵害。本文将讨论氯喹作为联合疗法用于改善癌症治疗的应用。
Zotero 插件