Department of International Physical Examination Center, The First Hospital of China Medical University, Shengyang, People's Republic of China.
Department of Endodontics, School of Stomatology, China Medical University, Shenyang, People's Republic of China.
Int J Nanomedicine. 2023 Oct 16;18:5797-5814. doi: 10.2147/IJN.S427116. eCollection 2023.
Sepsis is a systemic inflammatory reaction caused by infection. Severe sepsis can lead to multiple organ dysfunction, with a high incidence rate and mortality. The molecular pathogenesis of sepsis is complex and diverse. In recent years, with further study of the role of extracellular vesicles (EVs) in inflammatory diseases, it has been found that EVs play a dual role in the imbalance of inflammatory response in sepsis. Due to the great advantages such as lower toxicity, lower immunogenicity compared with stem cells and better circulation stability, EVs are increasingly used for the diagnosis and treatment of sepsis. The roles of EVs in the pathogenesis, diagnosis and treatment of sepsis were summarized to guide further clinical studies.
脓毒症是由感染引起的全身性炎症反应。严重脓毒症可导致多器官功能障碍，发病率和死亡率高。脓毒症的分子发病机制复杂多样。近年来，随着对细胞外囊泡（EVs）在炎症性疾病中作用的进一步研究，发现 EVs 在脓毒症炎症反应失衡中发挥双重作用。由于 EVs 与干细胞相比具有毒性更低、免疫原性更低、循环稳定性更好等优点，因此越来越多地被用于脓毒症的诊断和治疗。本文总结了 EVs 在脓毒症发病机制、诊断和治疗中的作用，以指导进一步的临床研究。
