Serhan Karolina, Gartung Allison, Panigrahy Dipak
Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States; Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States; Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States.
Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States; Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States; Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States.
Prostaglandins Other Lipid Mediat. 2018 Jul;137:40-45. doi: 10.1016/j.prostaglandins.2018.06.001. Epub 2018 Jun 19.
Ovarian cancer is the most lethal gynecologic malignancy among women. Due to the heterogeneity and complexity of the disease, as well as the insidious onset of symptoms, timely diagnosis remains extremely challenging. Despite recent advances in chemotherapy regimens for ovarian cancer patients, many still suffer from recurrence and ultimately succumb to the disease; thus, there is an urgent need for the identification of novel therapeutic targets. Within this rapidly evolving field, the role of platelets in the ovarian cancer tumor microenvironment has garnered increased attention. It is well-established that platelets and tumor cells exhibit bidirectional communication in which platelets enhance tumor cell invasion, extravasation, and protection from host system defenses, while tumor cells serve as platelet agonists, increasing platelet adhesion, aggregation, and degranulation. This mini-review focuses on the platelet-tumor cell relationship in ovarian cancer, specifically highlighting the essential role of bioactive lipid mediators at this interface.
卵巢癌是女性中最致命的妇科恶性肿瘤。由于该疾病的异质性和复杂性，以及症状的隐匿性发作，及时诊断仍然极具挑战性。尽管卵巢癌患者的化疗方案最近有所进展，但许多患者仍会复发并最终死于该疾病；因此，迫切需要确定新的治疗靶点。在这个快速发展的领域中，血小板在卵巢癌肿瘤微环境中的作用受到了越来越多的关注。众所周知，血小板与肿瘤细胞表现出双向通讯，其中血小板增强肿瘤细胞的侵袭、外渗并保护其免受宿主系统防御，而肿瘤细胞则作为血小板激动剂，增加血小板的粘附、聚集和脱颗粒。本综述聚焦于卵巢癌中血小板与肿瘤细胞的关系，特别强调生物活性脂质介质在这一界面的重要作用。
