变应性接触性皮炎诱导的立体特异性。

Allergic Contact Dermatitis-Induced Stereospecificity.

机构信息

From the Department of Dermatology, University of California, San Francisco.

出版信息

Dermatitis. 2021;32(1):10-14. doi: 10.1097/DER.0000000000000383.

Abstract

Frequent allergens are known, but not whether allergens are enantiomer specific. Chemicals were tested on guinea pigs and humans to answer this question. Frullanoides showed evident allergic enantiospecificity, whereas the conclusion was shaded for α-methylene-γ-butyrolactone. A link between this chemical and chronic actinic dermatitis was proposed. No clear tendency to enantio-stereospecificity in inducing allergic contact dermatitis was ascertained. Future studies using contemporary analytical chemistry and new immunologic knowledge have to be undertaken to provide clearer mechanistic insights. This information may aid in attempts to decrease product allergenicity.

摘要

已知常见过敏原，但不知道过敏原是否具有对映体特异性。为了回答这个问题，对豚鼠和人类进行了化学物质测试。Frullanoides 表现出明显的过敏对映体特异性，而对于 α-亚甲基-γ-丁内酯则得出了不确定的结论。有人提出这种化学物质与慢性光化性皮炎之间存在联系。在诱导过敏性接触性皮炎方面，没有确定对映体立体特异性的明显趋势。需要进行未来的研究，使用当代分析化学和新的免疫学知识，以提供更清晰的机制见解。这些信息可能有助于减少产品的过敏性。