From Schipslootweg 5, Wapserveen, the Netherlands.
Dermatitis. 2019 Nov/Dec;30(6):331-335. doi: 10.1097/DER.0000000000000465.
Limonene is a fragrance widely used in cosmetics and household products. Until recently, contact allergy to limonene was considered rare because positive patch tests to it were infrequently observed. In recent years, however, it has been demonstrated that exposure of limonene to oxygen (air) results in the formation of a number of oxidation products, of which the hydroperoxides have a far stronger sensitizing potency than the pure compound. By routine testing of patients suspected of contact dermatitis with hydroperoxides of limonene, high frequencies of positive reactions were found, indicating that these chemicals are important fragrance allergens. It should be realized, however, that a number of "positive" reactions may well be false-positive, irritant responses.
柠檬烯是一种广泛应用于化妆品和家用产品的香料。直到最近，人们还认为柠檬烯的接触过敏很少见，因为很少观察到它的阳性斑贴试验。然而，近年来已经证明，柠檬烯暴露于氧气（空气）中会形成许多氧化产物，其中过氧化物的致敏能力远远强于纯化合物。通过对疑似接触性皮炎患者进行柠檬烯过氧化物的常规测试，发现了高频率的阳性反应，这表明这些化学物质是重要的香料过敏原。然而，应该意识到，许多“阳性”反应很可能是假阳性的刺激性反应。
