Gao Lin, Xia Xiuwen, Shuai Yinqi, Zhang Hong, Jin Wei, Zhang Xiaoyun, Zhang Yi
Emergency Department, Chengdu University of Traditional Chinese Medicine Affiliated Hospital, Chengdu, Sichuan, China.
School of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
Front Pharmacol. 2023 Apr 13;14:1164150. doi: 10.3389/fphar.2023.1164150. eCollection 2023.
Acute ischemic stroke (AIS) is one of the leading diseases causing death and disability worldwide, and treatment options remain very limited. Traditional Chinese Medicine (TCM) has been used for thousands of years to treat ischemic stroke and has been proven to have significant efficacy, but its mechanism of action is still unclear. As research related to the brain-gut-microbe axis progresses, there is increasing evidence that the gut microbiota plays an important role during AIS. The interaction between TCM and the gut microbiota has been suggested as a possible key link to the therapeutic effects of TCM. We have compiled and reviewed recent studies on the relationship between AIS, TCM, and gut microbiota, with the expectation of providing more ideas to elucidate the mechanism of action of TCM in the treatment of AIS.
急性缺血性卒中（AIS）是全球导致死亡和残疾的主要疾病之一，治疗选择仍然非常有限。中医已经用于治疗缺血性卒中数千年，并已被证明具有显著疗效，但其作用机制仍不清楚。随着与脑-肠-微生物轴相关的研究进展，越来越多的证据表明肠道微生物群在急性缺血性卒中期间发挥重要作用。中医与肠道微生物群之间的相互作用被认为是中医治疗效果的一个可能关键环节。我们汇编并综述了近期关于急性缺血性卒中、中医和肠道微生物群之间关系的研究，期望提供更多思路以阐明中医治疗急性缺血性卒中的作用机制。
