正常血液和扁桃体B淋巴细胞群体中EBV靶细胞的表面标志物特征
Surface marker characterization of EBV target cells in normal blood and tonsil B lymphocyte populations.
作者信息
Aman P, Gordon J, Lewin N, Nordström M, Ehlin-Henriksson B, Klein G, Carstensson A
出版信息
J Immunol. 1985 Oct;135(4):2362-7.
PMID:2993411
Abstract
Human FACS-sorted B lymphocyte subpopulations were investigated for their susceptibility to immortalization by Epstein Barr virus (EBV). Only B cells reacting with the monoclonal antibody B2 were immortalized, whereas cells reacting with anti-human IgG or the monoclonal antibody BB2 were not responding. Cells positive or negative for IgM, IgD, Burkitt's lymphoma antigen (BLA), BB1, and HB2 were all transformed by EBV.
摘要
对通过荧光激活细胞分选术（FACS）分选的人B淋巴细胞亚群进行了研究，以考察它们对爱泼斯坦-巴尔病毒（EBV）永生化的敏感性。只有与单克隆抗体B2发生反应的B细胞被永生化，而与抗人IgG或单克隆抗体BB2发生反应的细胞则无反应。IgM、IgD、伯基特淋巴瘤抗原（BLA）、BB1和HB2呈阳性或阴性的细胞均被EBV转化。
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