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本文引用的文献

1
1958 Revision of diagnostic criteria for rheumatoid arthritis.1958年类风湿关节炎诊断标准修订版。
Bull Rheum Dis. 1958 Dec;9(4):175-6.
2
Rosette formation with mouse erythrocytes defines a population of human B lymphocytes unresponsive to pokeweed mitogen.与小鼠红细胞形成玫瑰花结可界定一群对商陆有丝分裂原无反应的人B淋巴细胞。
Clin Exp Immunol. 1981 Jul;45(1):185-90.
3
Evidence for B cell activation in patients with active rheumatoid arthritis.活动性类风湿关节炎患者B细胞活化的证据。
Clin Exp Immunol. 1984 Jan;55(1):91-8.
4
Decreased pokeweed mitogen-induced IgM and IgM rheumatoid factor synthesis in rheumatoid arthritis patients treated with gold sodium thiomalate or penicillamine.
Arthritis Rheum. 1984 Sep;27(9):985-94. doi: 10.1002/art.1780270904.
5
Response of human B cells to Staphylococcus aureus Cowan I: T-independent proliferation and T-dependent differentiation to immunoglobulin secretion involve subsets separable by rosetting with mouse erythrocytes.人B细胞对金黄色葡萄球菌考恩I型菌株的反应：非T细胞依赖性增殖和向免疫球蛋白分泌的T细胞依赖性分化涉及可通过与小鼠红细胞形成玫瑰花结而分离的亚群。
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Two different rheumatoid factor-producing cell populations distinguished by the mouse erythrocyte receptor and responsiveness to polyclonal B cell activators.
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Identification of a 145,000 Mr membrane protein as the C3d receptor (CR2) of human B lymphocytes.鉴定一种145,000道尔顿的膜蛋白为人B淋巴细胞的C3d受体（CR2）。
Proc Natl Acad Sci U S A. 1984 Feb;81(3):881-5. doi: 10.1073/pnas.81.3.881.
8
Characterization of a human B cell-specific antigen (B2) distinct from B1.一种不同于B1的人B细胞特异性抗原（B2）的特性分析。
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9
Characterization of a human B lymphocyte-specific antigen.一种人类B淋巴细胞特异性抗原的特性描述。
J Immunol. 1980 Oct;125(4):1678-85.
10
Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g.从人血中分离单核细胞和粒细胞。通过一次离心分离单核细胞，通过离心和1g沉降相结合的方法分离粒细胞。
Scand J Clin Lab Invest Suppl. 1968;97:77-89.

类风湿关节炎外周血B淋巴细胞上CD21、CD22及小鼠红细胞受体的表达

Expression of CD 21, CD 22, and the mouse erythrocyte receptor on peripheral B lymphocytes in rheumatoid arthritis.

作者信息

Hildebrandt S, von der Heydt I, von Wichert P

机构信息

University Hospital of Internal Medicine, Marburg, Federal Republic of Germany.

出版信息

Ann Rheum Dis. 1988 Jul;47(7):588-94. doi: 10.1136/ard.47.7.588.

DOI:10.1136/ard.47.7.588
PMID:2969703
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1003575/
Abstract

The expression of the B cell antigens, CD 21, CD 22, and the mouse erythrocyte receptor (MER), on peripheral mononuclear cells (PMC) in 61 patients with rheumatoid arthritis (RA) and in 25 patients with various other forms of rheumatic disease was studied. Patients with RA showed significantly more peripheral B cells than control patients, whereas there was no difference between patients with RA and controls in resting B cells expressing the MER or resting and activated B cells expressing CD 21. Patients with active RA had significantly less MER positive and more CD 21 positive B cells than patients with inactive disease. The relation between disease activity and expression of MER and CD 21 was independent of drug treatment or production of classical rheumatoid factor. These data may be interpreted as a sign of B cell activation in RA. In addition, patients with seronegative RA receiving gold treatment showed significantly more MER positive cells than patients receiving different drugs, whereas patients receiving non-steroidal anti-inflammatory drugs (NSAIDs) alone had significantly more CD 21 positive cells. This may be the result of different immunomodulating effects of drugs on B cell subsets.

摘要

对61例类风湿关节炎（RA）患者和25例患有其他各种形式风湿性疾病的患者外周血单个核细胞（PMC）上B细胞抗原CD 21、CD 22及小鼠红细胞受体（MER）的表达进行了研究。RA患者外周血B细胞显著多于对照患者，而表达MER的静止B细胞或表达CD 21的静止及活化B细胞在RA患者与对照之间并无差异。活动期RA患者的MER阳性B细胞显著少于非活动期患者，而CD 21阳性B细胞则显著多于非活动期患者。疾病活动与MER和CD 21表达之间的关系独立于药物治疗或经典类风湿因子的产生。这些数据可解释为RA中B细胞活化的一个迹象。此外，接受金制剂治疗的血清阴性RA患者的MER阳性细胞显著多于接受其他不同药物治疗的患者，而仅接受非甾体抗炎药（NSAIDs）治疗的患者的CD 21阳性细胞显著增多。这可能是药物对B细胞亚群产生不同免疫调节作用的结果。