Tsuchie H, Kurimura T, Hinuma Y
J Infect. 1985 May;10(3):272-6. doi: 10.1016/s0163-4453(85)92788-4.
An indirect immunofluorescence method was developed for the assay of antibodies to lymphadenopathy-associated virus (LAV) which is known to be associated with the aetiology of the acquired immunodeficiency syndrome (AIDS). Samples of serum or plasma from 1353 healthy volunteer blood donors, 53 homosexual males, 29 patients who had received multiple blood transfusions and 163 haemophiliacs in Japan were tested for antibody to LAV. Results showed that 47 (29%) of the haemophiliacs, who had been treated largely with factor VIII or IX produced in the USA, were anti-LAV antibody positive, whereas all other subjects were anti-LAV antibody negative. The incidence of antibodies to Adult T-cell leukaemia virus or Human T-cell leukaemia virus I (ATLV or HTLV-I) in these subjects was high.
已开发出一种间接免疫荧光法，用于检测与淋巴结病相关病毒（LAV）的抗体，已知该病毒与获得性免疫缺陷综合征（AIDS）的病因有关。对日本1353名健康志愿献血者、53名同性恋男性、29名接受多次输血的患者和163名血友病患者的血清或血浆样本进行了LAV抗体检测。结果显示，主要接受美国生产的VIII或IX因子治疗的47名（29%）血友病患者抗LAV抗体呈阳性，而所有其他受试者抗LAV抗体均为阴性。这些受试者中成人T细胞白血病病毒或人类T细胞白血病病毒I（ATLV或HTLV-I）抗体的发生率很高。
