Cheingsong-Popov R, Weiss R A, Dalgleish A, Tedder R S, Shanson D C, Jeffries D J, Ferns R B, Briggs E M, Weller I V, Mitton S
Lancet. 1984 Sep 1;2(8401):477-80. doi: 10.1016/s0140-6736(84)92562-5.
2000 persons in the UK were examined serologically for antibodies to human T-lymphotropic virus type III (HTLV-III). Sera reacting in a membrane immunofluorescence assay (IFA) to HTLV-III were also positive when tested against cells infected with lymphadenopathy virus (LAV-1), and cross-adsorption tests indicated that these retroviruses are probably identical. A competitive radioimmunoassay (RIA), which was wholly concordant with IFA, was used to screen the sera. 30/31 patients with the acquired immunodeficiency syndrome (AIDS) were seropositive, as were 89% patients with persistent generalised lymphadenopathy (PGL), 17% symptomless homosexual men, 34% haemophiliacs receiving pooled clotting factors, and 1.5% intravenous drug abusers. None of more than 1000 unselected blood donors was seropositive. These data confirm the close association between HTLV-III and AIDS and PGL and show that infection with HTLV-III is also prevalent in the populations in whom these syndromes are most likely to develop. However, it would be unwise to presume that AIDS will necessarily develop in seropositive subjects.
对英国2000人进行了血清学检测，以检测人类嗜T淋巴细胞病毒III型（HTLV-III）抗体。在膜免疫荧光试验（IFA）中与HTLV-III发生反应的血清，在针对感染淋巴结病病毒（LAV-1）的细胞进行检测时也呈阳性，交叉吸附试验表明这些逆转录病毒可能是相同的。一种与IFA完全一致的竞争性放射免疫测定法（RIA）被用于筛查血清。30/31例获得性免疫缺陷综合征（AIDS）患者血清呈阳性，持续性全身性淋巴结病（PGL）患者中89%血清呈阳性，无症状同性恋男性中17%血清呈阳性，接受混合凝血因子的血友病患者中34%血清呈阳性，静脉注射吸毒者中1.5%血清呈阳性。超过1000名未经挑选的献血者中无一血清呈阳性。这些数据证实了HTLV-III与AIDS和PGL之间的密切关联，并表明HTLV-III感染在最有可能发生这些综合征的人群中也很普遍。然而，假定血清呈阳性的个体一定会患上AIDS是不明智的。
