体外受精或卵胞浆内单精子注射失败且精子 DNA 碎片化升高的夫妇在下一个周期是否应该使用睾丸精子？
Should a Couple with Failed In Vitro Fertilization or Intracytoplasmic Sperm Injection and Elevated Sperm DNA Fragmentation Use Testicular Sperm for the Next Cycle?
机构信息
ANDROFERT, Andrology and Human Reproduction Clinic, Campinas, Brazil; Department of Surgery, Division of Urology, Faculty of Medical Sciences, University of Campinas (UNICAMP), Campinas, Brazil; Faculty of Health, Aarhus University, Aarhus, Denmark.
出版信息
Eur Urol Focus. 2018 Apr;4(3):296-298. doi: 10.1016/j.euf.2018.06.001. Epub 2018 Jun 20.
There is growing evidence indicating that intracytoplasmic sperm injection with testicular sperm rather than ejaculated sperm might be advantageous in achieving pregnancy for couples in which the male has high levels of sperm DNA fragmentation (SDF). Meta-analysis has shown that SDF rates are markedly lower in testicular sperm than in ejaculated sperm, and the odds of achieving pregnancy and a live birth are significantly higher.
越来越多的证据表明，对于精子 DNA 碎片化（SDF）水平较高的男性夫妇，使用睾丸精子进行胞浆内单精子注射可能比使用射出精子更有利于妊娠。荟萃分析显示，睾丸精子中的 SDF 率明显低于射出精子，并且妊娠和活产的几率显著更高。
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